Chinese Journal of Lasers, Volume. 47, Issue 2, 207025(2020)

Identification of Human Coronary Atherosclerotic Plaques using Spectrum- and Time-Resolved Multiphoton Microscopy

Zhang Rongli1,2,3, Li Hui3, Wu Yueheng4, Yu Jia3, Liu Shangmin5, Zheng Wei3, and Lin Zhanyi1,2
Author Affiliations
  • 1School of Medicine, South China University of Technology, Guangzhou, Guangdong 510006, China
  • 2Guangdong Provincial People''s Hospital, South China University of Technology, Guangzhou, Guangdong 510080, China
  • 3Research Laboratory for Biomedical Optics and Molecular Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China
  • 4Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong Provincial People''s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080, China
  • 5Research Department of Medical Sciences, Guangdong Academy of Medical Sciences, Guangdong Provincial People''s Hospital, Guangzhou, Guangdong 510080, China
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    Figures & Tables(4)
    Spectrum-coded images with different depths and the corresponding 3D images and histology of CAP and non-CAP regions in human coronary arterial intima. (a) Spectrum-coded images; (b) 3D structure images; (c) pathological images. The right color band represents the range of spectral: 404.58--592.08 nm
    Spectral characteristics of the multiple components of the normal and diseased human intima of coronary artery. (a) TPEF spectra of non-CAP and CAP regions; (b) ratio of TPEF to SHG signal from non-CAP and CAP regions of eight samples(**means 0.001PP represents significance level)
    Fluorescence lifetime-code images with different depths of the non-CAP and CAP lesion human coronary arterial intima. The right color band represents the range of spectral fluorescence lifetime: 0.5--2.5 ns
    Quantitative fluorescence lifetime of the biochemical components of normal and AP regions from human coronary arterial wall (*** means P<0.001)
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    Zhang Rongli, Li Hui, Wu Yueheng, Yu Jia, Liu Shangmin, Zheng Wei, Lin Zhanyi. Identification of Human Coronary Atherosclerotic Plaques using Spectrum- and Time-Resolved Multiphoton Microscopy[J]. Chinese Journal of Lasers, 2020, 47(2): 207025

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    Paper Information

    Category: biomedical photonics and laser medicine

    Received: Oct. 8, 2019

    Accepted: --

    Published Online: Feb. 21, 2020

    The Author Email:

    DOI:10.3788/CJL202047.0207025

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