Acta Physica Sinica, Volume. 68, Issue 21, 214304-1(2019)

Mechanism of contrast-enhancement in ultrasound-modulated laser feedback imaging with ultrasonicmicrobubble contrast agent

Bo-Rui Zhou1,2, Yi-Dong Tan2、*, Xue-Ju Shen1、*, Kai-Yi Zhu2, and Li-Ping Bao3
Author Affiliations
  • 1Department of Electronic and Optical Engineering, Army Engineering University of PLA, Shijiazhuang 050051, China
  • 2State Key Laboratory of Precision Measurement Technology and Instrument, Tsinghua University, Beijing 100084, China
  • 3Department of Ultrasound, Peking University Cancer Hospital, Beijing 100042, China
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    Figures & Tables(12)
    Schematic of ULFI technology.ULFI技术原理图
    Schematic diagram of interaction among microbubbles, light field and sound field.微泡、光场、声场相互作用示意图
    Ultrasonic dynamics of microbubble: (a) Curve of microbubble radius; (b) spectrogram of microbubble radius.微泡的超声动态特性 (a)微泡半径变化曲线; (b)微泡半径变化频谱图
    Curves of microbubble scattering acoustic pressure.微泡散射声压曲线
    Curves of microbubbles scattering coefficient.微泡群散射系数变化曲线
    Flow chart of optical scattering parameters selection in Monte Carlo simulation.蒙特卡罗仿真光散射参数的选择流程图
    Monte Carlo simulation of backscattered spot patterns: (a) 0.9% NaCl; (b) 0.9% NaCl with microbubbles; (c) 1% intralipid; (d) 1% intralipid with microbubbles.蒙特卡罗仿真背向散射光斑图 (a) 0.9% NaCl; (b) 0.9% NaCl添加微泡; (c) 1%的脂肪乳剂; (d) 1%的脂肪乳剂添加微泡
    Experiment system.实验系统
    Acoustic pressure-ULFI signal curve of the microbubble solution and 0.9% NaCl solution: (a) Total curve; (b) fundamental signal; (c) second harmonic signal; (d) third harmonic signal.微泡溶液和0.9%NaCl溶液中的声压-ULFI信号曲线 (a)总曲线; (b)基波信号; (c)二次谐波信号; (d)三次谐波信号
    Acoustic pressure-ULFI signal curves of 1% intralipid solution and microbubble intralipid mixed solution.1%的脂肪乳剂溶液和微泡、脂肪乳剂混合溶液中的声压-ULFI信号曲线
    • Table 1.

      Rayleigh-Plesset equation simulation parameters.

      Rayleigh-Plesset方程仿真参数

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      Table 1.

      Rayleigh-Plesset equation simulation parameters.

      Rayleigh-Plesset方程仿真参数

      ${\rho _{\rm{L}}}/{\rm{kg}} \cdot {{\rm{m}}^{ - 3}}$${P_0}/{\rm{kPa}}$$\sigma /{\rm{N}} \cdot {{\rm{m}}^{ - 1}}$$\chi /{\rm{N}} \cdot {{\rm{m}}^{ - 1}}$$c/{\rm{m}} \cdot {{\rm{s}}^{ - 1}}$$\varepsilon /{\rm{nm}}$${\mu _{{\rm{sh}}}}/{\rm{Pa}} \cdot {\rm{s}}$$\gamma $
      99810100.0510.26150050.0031.07
    • Table 2.

      Results of Monte Carlo simulation.

      蒙特卡罗仿真结果

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      Table 2.

      Results of Monte Carlo simulation.

      蒙特卡罗仿真结果

      溶液种类背向散射光子数$\dfrac{{{\simfont\text{调制}} + {\simfont\text{附加调制}}}}{{\simfont\text{未调制}}}$
      调制未调制附加调制
      0.9%的NaCl溶液935445080020.75%
      0.9%的NaCl、微泡混合液937946070460730.36%
      1%的脂肪乳剂溶液8435296601.59%
      1%的脂肪乳剂、微泡混合液975268570.20%
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    Bo-Rui Zhou, Yi-Dong Tan, Xue-Ju Shen, Kai-Yi Zhu, Li-Ping Bao. Mechanism of contrast-enhancement in ultrasound-modulated laser feedback imaging with ultrasonicmicrobubble contrast agent[J]. Acta Physica Sinica, 2019, 68(21): 214304-1

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    Paper Information

    Received: May. 20, 2019

    Accepted: --

    Published Online: Sep. 17, 2020

    The Author Email: Shen Xue-Ju (shxjoptics@aliyun.com)

    DOI:10.7498/aps.68.20190770

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