Acta Laser Biology Sinica, Volume. 34, Issue 2, 176(2025)

Rapamycin Alleviates High-sugar Induced Podocyte Damage by Inhibiting the NLRP3 Inflammasome

ZHAO Xuehui*, WANG Huaihuai, LI Weiwei, LI Yingjie, and JIA Junli
Author Affiliations
  • Department of Nephrology, the Second Affiliated Hospital of Hebei North University, Zhangjiakou 075000, China
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    References(13)

    [1] [1] LI X, LU L, HOU W,et al. Epigenetics in the pathogenesis of diabetic nephropathy[J]. Acta Biochimica Et Biophysica Sinica, 2022, 54(2): 163-172.

    [2] [2] BARUTTA F, BELLINI S, GRUDEN G. Mechanisms of podocyte injury and implications for diabetic nephropathy[J]. Clinical Science, 2022, 136(7): 493-520.

    [3] [3] HOU Y, LIN S, QIU J,et al. NLRP3 inflammasome negatively regulates podocyte autophagy in diabetic nephropathy[J]. Biochemical and Biophysical Research Communications, 2020, 521(3): 791-798.

    [4] [4] ABOU DAHER A, ALKHANSA S, AZAR W S,et al. Translational aspects of the mammalian target of rapamycin complexes in diabetic nephropathy[J]. Antioxidants & Redox Signaling, 2022, 37(10/12): 802-819.

    [8] [8] KRISTENSEN S L, RRTH R, JHUND P S,et al. Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials[J]. The Lancet Diabetes & Endocrinology, 2019, 7(10): 776-785.

    [9] [9] ALOMARI G, AL-TRAD B, HAMDAN S,et al. Gold nanoparticles attenuate albuminuria by inhibiting podocyte injury in a rat model of diabetic nephropathy[J]. Drug Delivery and Translational Research, 2020, 10(1): 216-226.

    [10] [10] WU L, LIU C, CHANG D Y,et al. Annexin A1 alleviates kidney injury by promoting the resolution of inflammation in diabetic nephropathy[J]. Kidney International, 2021, 100(1): 107-121.

    [11] [11] METLAY J P, WATERER G W. Treatment of community-acquired pneumonia during the coronavirus disease 2019 (COVID-19) pandemic[J]. Annals of Internal Medicine, 2020, 173(4): 304-305.

    [12] [12] TANG B, ZHU J, FANG S,et al. Pharmacological inhibition of MELK restricts ferroptosis and the inflammatory response in colitis and colitis-propelled carcinogenesis[J]. Free Radical Biology and Medicine, 2021, 172: 312-329.

    [15] [15] SHI H, ZHAO Y, HE T,et al. Rapamycin attenuated podocyte apoptosis via upregulation of nestin in Ang II-induced podocyte injury[J]. Molecular Biology Reports, 2022, 49(3): 2119-2128.

    [17] [17] LI D, REN W, JIANG Z,et al. Regulation of the NLRP3 inflammasome and macrophage pyroptosis by the p38 MAPK signaling pathway in a mouse model of acute lung injury[J]. Molecular Medicine Reports, 2018, 18(5): 4399-4409.

    [18] [18] ZHOU R, YANG X, LI X,et al. Recombinant CC16 inhibits NLRP3/caspase-1-induced pyroptosis through p38 MAPK and ERK signaling pathways in the brain of a neonatal rat model with sepsis[J]. Journal of Neuroinflammation, 2019, 16(1): 239.

    [20] [20] LONG C, LIN Q, MO J,et al. Hirudin attenuates puromycin aminonucleoside-induced glomerular podocyte injury by inhibiting MAPK-mediated endoplasmic reticulum stress[J]. Drug Development Research, 2022, 83(4): 1047-1056.

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    ZHAO Xuehui, WANG Huaihuai, LI Weiwei, LI Yingjie, JIA Junli. Rapamycin Alleviates High-sugar Induced Podocyte Damage by Inhibiting the NLRP3 Inflammasome[J]. Acta Laser Biology Sinica, 2025, 34(2): 176

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    Paper Information

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    Received: Jul. 20, 2024

    Accepted: Jul. 24, 2025

    Published Online: Jul. 24, 2025

    The Author Email: ZHAO Xuehui (zhaoxuehui8612@163.com)

    DOI:10.3969/j.issn.1007-7146.2025.02.010

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