Chinese Journal of Lasers, Volume. 50, Issue 15, 1507207(2023)
Far Infrared Spectrum of Antithrombotic Drug Xarelto
Figures & Tables(7)
Fig. 1. Theoretical simulation results of Xarelto. (a) Molecular model; (b) theoretical spectral diagram
Fig. 2. Experimental results of qualitative detection of Xarelto. (a) Time domain diagram with schematic of detection shown in inset; (b) frequency domain diagram
Fig. 4. Theoretical vibration modes of Xarelto at different theoretical peaks. (a) 40.22 cm-1; (b) 81.38cm-1; (c) 100.60 cm-1
Fig. 5. Absorption spectra of samples with different Xarelto masses. (a) Before baseline removal; (b) after baseline removal
Table 1. Corresponding relationship between theoretical peak and measured peak of Xarelto as well as corresponding molecular motion pattern
View tableTable 1. Corresponding relationship between theoretical peak and measured peak of Xarelto as well as corresponding molecular motion pattern
Theoretical peak Measured peak Deviation Molecular motion pattern 24.00 cm-1
（shoulder peak）
38.87 cm-1
（shoulder peak）
14.870 cm-1 Twisting（—NC4H6O2）+ rocking（—CH2—）+
rocking（—C4H2ClS）
40.22 cm-1 49.03 cm-1 8.810 cm-1 Twisting（—NC4H6O2） 72.63 cm-1
（shoulder peak）
72.66 cm-1
（shoulder peak）
0.030 cm-1 Twisting（—NC4H6O2） 81.38 cm-1 80.54 cm-1 0.084 cm-1 Twisting（—Ph）+ twisting（—NC4H6O2） 100.60 cm-1 96.29 cm-1 4.310 cm - 1Rocking（—COC—）
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Xiaoke Wei, Xu Wu, Xiaosen Lu, Junjie Wang, Jingnan Li, Yansi Yang, Xinbo Chu, Qiliang Wang, Zuanming Jin, Yan Peng. Far Infrared Spectrum of Antithrombotic Drug Xarelto[J]. Chinese Journal of Lasers, 2023, 50(15): 1507207
Paper Information
Category: Optical Diagnostics and Therapy
Received: Feb. 14, 2023
Accepted: Apr. 3, 2023
Published Online: Jul. 31, 2023
The Author Email: Wu Xu (wuxu@usst.edu.cn)
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