Journal of Tongji University(Medical Science), Volume. 46, Issue 3, 333(2025)

Hyperthermic intraperitoneal chemotherapy improves survival and prognosis in patients with advanced gastrointestinal malignant ascites: a single-center retrospective clinical study

KE Zhui1, GAO Jie1, LUO Xinpei1, LU Jingyi1, ZHANG Zhenshan2, GUO Xianling1, YUAN Min1, LIU Zhuqing1, HE Xuemin1, and XU Qing1、*
Author Affiliations
  • 1Department of Oncology, Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China
  • 2Department of Oncology, Fudan University Affiliated Tumor Hospital, Shanghai 200032, China
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    References(22)

    [1] [1] SUNG H, FERLAY J, SIEGEL R L, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2021, 71(3): 209-49.

    [2] [2] VALDERRAMA-TREVIO A I, BARRERA-MERA B, CEBALLOS-VILLALVA J C, et al. Hepatic metastasis from colorectal cancer[J]. Euroasian J Hepato-gastroenterol, 2017, 7(2): 166-175.

    [3] [3] PRABHU A, MISHRA D, BRANDL A, et al. Gastric cancer with peritoneal metastasis-a comprehensive review of current intraperitoneal treatment modalities[J]. Front Oncol, 2022, 12: 864647.

    [4] [4] HODGE C, BADGWELL B D. Palliation of malignant ascites[J]. J Surg Oncol, 2019, 120(1): 67-73.

    [5] [5] VAN STEIN R M, AALBERS A G J, SONKE G S, et al. Hyperthermic intraperitoneal chemotherapy for ovarian and colorectal cancer: a review[J]. JAMA Oncology, 2021, 7(8): 1231-1238.

    [7] [7] STUKAN M. Drainage of malignant ascites: patient selection and perspectives[J]. Cancer Manag Res, 2017, 9: 115-130.

    [8] [8] BA M, CUI S, LONG H, et al. Safety and effectiveness of high-precision hyperthermic intraperitoneal perfusion chemotherapy in peritoneal carcinomatosis: a real-world study[J]. Front Oncol, 2021, 11: 674915.

    [9] [9] CEELEN W, HELENA B, GABRIELLE V R, et al. Intraperitoneal chemotherapy for peritoneal metastases: an expert opinion[J]. Expert Opin Drug Del, 2020, 17(4): 511-522.

    [10] [10] GUCHELAAR N A D, NOORDMAN B J, KOOLEN S L W, et al. Intraperitoneal chemotherapy for unre-sectable peritoneal surface malignancies[J]. Drugs, 2023, 83(2): 159-180.

    [11] [11] JI Z, SUN J, WU H, et al. Assessment of hyperthermic intraperitoneal chemotherapy to eradicate intraperitoneal free cancer cells[J]. Transl Oncol, 2016, 9(1): 18-24.

    [12] [12] NI X, WU P, WU J, et al. Hyperthermic intraperitoneal perfusion chemotherapy and response evaluation in patients with gastric cancer and malignant ascites[J]. Oncol Lett, 2017, 14(2): 1691-1696.

    [13] [13] JIAO J, LI C, YU G, et al. Efficacy of hyperthermic intraperitoneal chemotherapy (HIPEC) in the management of malignant ascites[J]. World J Surg Oncol, 2020, 18(1): 180.

    [15] [15] LI Y, LIU B, YANG F, et al. Lobaplatin induces BGC-823 human gastric carcinoma cell apoptosis via ROS- mitochondrial apoptotic pathway and impairs cell migration and invasion[J]. Biomed Pharmacother, 2016, 83: 1239-1246.

    [16] [16] YU J, LI S, QI J, et al. Cleavage of GSDME by caspase-3 determines lobaplatin-induced pyroptosis in colon cancer cells[J]. Cell Death Dis, 2019, 10(3): 193.

    [17] [17] MAURICI C E, COLENBIER R, WYLLEMAN B, et al. Hyperthermia enhances efficacy of chemotherapeutic agents in pancreatic cancer cell lines[J]. Biomolecules, 2022, 12(5): 651.

    [18] [18] DORIGO O, BEREK J S. Personalizing CA125 levels for ovarian cancer screening[J]. Cancer Prev Res (Phila), 2011, 4(9): 1356-1359.

    [19] [19] WINARNO G N A, HIDAYAT Y M, SOETOPO S, et al. The role of CA-125, GLS and FASN in predicting cytoreduction for epithelial ovarian cancers[J]. BMC Research Notes, 2020, 13(1): 346.

    [20] [20] WANG Q, FENG X, LIU X, et al. Prognostic value of elevated pre-treatment serum CA-125 in epithelial ovarian cancer: a meta-analysis[J]. Front Oncol, 2022, 12: 868061.

    [21] [21] PIATEK S, PANEK G, LEWANDOWSKI Z, et al. Rising serum CA-125 levels within the normal range is strongly associated recurrence risk and survival of ovarian cancer[J]. J Ovarian Res, 2020, 13(1): 102.

    [22] [22] DOCHEZ V, CAILLON H, VAUCEL E, et al. Biomarkers and algorithms for diagnosis of ovarian cancer: CA125, HE4, RMI and ROMA, a review[J]. J Ovarian Res, 2019, 12(1): 28.

    [23] [23] ZHONG Y, KANG W, HU H, et al. Lobaplatin-based prophylactic hyperthermic intraperitoneal chemotherapy for T4 gastric cancer patients: A retrospective clinical study[J]. Front Oncol, 2023, 13: 995618.

    [25] [25] LIU C, SHAN X, LIU Z. Analysis of adverse reactions and clinical rational drug use of antitumor drug paclitaxel[J]. Minerva medica, 2023, 8(4): 114.

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    KE Zhui, GAO Jie, LUO Xinpei, LU Jingyi, ZHANG Zhenshan, GUO Xianling, YUAN Min, LIU Zhuqing, HE Xuemin, XU Qing. Hyperthermic intraperitoneal chemotherapy improves survival and prognosis in patients with advanced gastrointestinal malignant ascites: a single-center retrospective clinical study[J]. Journal of Tongji University(Medical Science), 2025, 46(3): 333

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    Paper Information

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    Received: Jun. 16, 2024

    Accepted: Aug. 26, 2025

    Published Online: Aug. 26, 2025

    The Author Email: XU Qing (xuqingmd@aliyun.com)

    DOI:10.12289/j.issn.2097-4345.24247

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