Laser & Optoelectronics Progress, Volume. 61, Issue 18, 1800002(2024)

Principle and Clinical Quantitative Analysis of Optical Coherence Tomography Angiography

Di Wang1, Ting Zhang1, Shanshan Liang2、*, and Jun Zhang1、**
Author Affiliations
  • 1School of Life and Environmental Science, Guilin University of Electronic Science and Technology, Guilin 541004, Guangxi, China
  • 2National Innovation Center for Advanced Medical Devices, Shenzhen 518083, Guangdong, China
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    Figures & Tables(9)
    OCTA nearly 16 years published literature trend (source:https://www.ncbi.nlm.nih.gov/pubmed, in order to "optical coherence tomography angiography" as a keyword search)
    Split-spectrum diagram[32].(a) Schematic of band-pass filtering spectral analysis; (b) spectral analysis process of original 2D interferogram
    Inverse SNR-decorrelation asymptotic relation and its variance[40].(a) OCT data; (b)‒(d) ID asymptotic relation; (e) plot of standard variance to mean value of decorrelation for static voxels; (f) plot of squared coefficient of variance to spatio-temporal average kernel size for all static voxels
    Network architecture of vascular imaging based on CNN[45]
    Method for determining CNV area and bone[62]
    Retinal OCTA images of albino rats processed by three OCTA methods[67].(a) OCT fundus image; (b)‒(d) superficial retinas; (e) OCT cross-sectional image; (f)‒(h) deep in the retina; (i)‒(k) RPE layer of the retina; (l)‒(m) color-coded map of all layers of the retina
    Comparison of two OCTA algorithms in the evaluation of four quantitative indicators[67]
    • Table 1. Quantitative summary of OCTA features for different DR stages[54]

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      Table 1. Quantitative summary of OCTA features for different DR stages[54]

      ParameterVolunterMild NPDRModerate NPDRSevere NPDR
      VCIs1.11±0.051.12±0.041.18±0.051.21±0.04
      BVCs /μm17.84±0.0918.37±0.2820.43±0.1721.24±0.21
      VPIs10.57±0.229.97±0.618.93±0.097.84±0.37
      BVDs /%48.16±3.3245.62±2.1140±3.5236.84±2.45
      BVDd /%49.72±3.1845.98±3.0941.78±2.1737.46±3.16
      FAZAs /mm20.29±0.160.31±0.170.36±0.180.40±0.21
      FAZAd /mm20.46±0.170.47±0.150.52±0.110.58±0.26
      FAZCIs1.16±0.041.23±0.131.31±0.121.42±0.13
      FAZCId1.19±0.061.24±0.291.34±0.091.45±0.14
    • Table 2. Performance comparison between single and combined features[54]

      View table

      Table 2. Performance comparison between single and combined features[54]

      ParameterSensitivitySpecificityAccuracyAUC
      VCI81.0580.3680.6378.92
      BVC82.7880.9181.2980.48
      VPI89.6488.1089.7886.78
      BVD94.0693.7393.8991.87
      FAZA92.2591.7092.0290.79
      FAZCI93.8392.9893.4890.98
      Combined95.1793.8894.4192.33
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    Di Wang, Ting Zhang, Shanshan Liang, Jun Zhang. Principle and Clinical Quantitative Analysis of Optical Coherence Tomography Angiography[J]. Laser & Optoelectronics Progress, 2024, 61(18): 1800002

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    Paper Information

    Category: Reviews

    Received: Jan. 25, 2024

    Accepted: Mar. 4, 2024

    Published Online: Sep. 9, 2024

    The Author Email: Shanshan Liang (ss.liang@nmed.org.cn), Jun Zhang (junzhang8819@gmail.com)

    DOI:10.3788/LOP240603

    CSTR:32186.14.LOP240603

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