Laser & Optoelectronics Progress, Volume. 61, Issue 18, 1800002(2024)

Principle and Clinical Quantitative Analysis of Optical Coherence Tomography Angiography

Di Wang1, Ting Zhang1, Shanshan Liang2、*, and Jun Zhang1、**
Author Affiliations
  • 1School of Life and Environmental Science, Guilin University of Electronic Science and Technology, Guilin 541004, Guangxi, China
  • 2National Innovation Center for Advanced Medical Devices, Shenzhen 518083, Guangdong, China
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    Optical coherence tomography angiography (OCTA), derived from optical coherence tomography (OCT) technology, is a vascular imaging approach that leverages flowing red blood cells as an intrinsic contrast agent. It has key advantages, including high resolution, sensitivity, and noninvasiveness. By discerning the amplitude and phase variances within OCT signals between flowing red blood cells and stationary tissue, OCTA enables 3D imaging of the retinal vascular network. Leveraging vascular density, diameter, perimeter, and complexity indices, OCTA is a screening tool for ocular pathologies such as diabetic retinopathy (DR) and venous occlusion (VO), exhibiting notable efficacy in clinical interventions. This article provides an overview of the evolution of OCTA, elucidates its algorithmic fundamentals, delineates clinical quantitative metrics, and briefly evaluates the comparison between various OCTA methods and standard quantitative indicators.

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    Di Wang, Ting Zhang, Shanshan Liang, Jun Zhang. Principle and Clinical Quantitative Analysis of Optical Coherence Tomography Angiography[J]. Laser & Optoelectronics Progress, 2024, 61(18): 1800002

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    Paper Information

    Category: Reviews

    Received: Jan. 25, 2024

    Accepted: Mar. 4, 2024

    Published Online: Sep. 9, 2024

    The Author Email: Liang Shanshan (ss.liang@nmed.org.cn), Zhang Jun (junzhang8819@gmail.com)

    DOI:10.3788/LOP240603

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