Laser & Optoelectronics Progress, Volume. 62, Issue 18, 1817020(2025)

Handheld Multispectral Photoacoustic Imaging Probe for Label-Free Lipid Detection and Imaging Performance Optimization (Invited)

Chuanmiao Yu1,2, Shang Qiao2,3, Liangjian Liu2, Chengbo Liu2、***, Yunyao Zhang3、**, and Yaguang Ren2、*
Author Affiliations
  • 1Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 518000, Guangdong , China
  • 2Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, Guangdong , China
  • 3School of Information Science and Technology, Northwest University, Xi'an 710119, Shaanxi , China
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    Figures & Tables(4)
    Handheld multispectral photoacoustic imaging probe and system for lipid imaging
    Photoacoustic imaging and spectral analysis results of the oil sample in the tube and ex vivo adipose tissue. (a) Photograph of the PVC pipe filled with vegetable oil; (b) photoacoustic images of the oil sample inside the tube under 930 nm and 1210 nm excitation wavelengths, with H₂O and D₂O used as coupling media in the probe, respectively; (c) optical absorption spectra of H₂O, D2O, and lipid in the near-infrared region; (d) photoacoustic spectral curves of the oil sample in the tube under different combinations of coupling media and excitation wavelengths [corresponding to the imaging conditions in (b)]; (e) photograph of ex vivo white adipose tissue from mouse; (f) photoacoustic spectra of ex vivo adipose tissue under D2O coupling at different wavelengths; statistical comparison of photoacoustic signal intensities between the oil sample in the tube (g) and ex vivo adipose tissue (h) under 930 nm and 1210 nm excitations
    Photoacoustic imaging results of the pork belly phantom. (a) Photograph of pork belly phantom; (b) phantom photoacoustic images under 930 nm and 1210 nm excitations; (c) lipid images obtained via spectral unmixing at different wavelengths
    In vivo imaging result of abdominal adipose tissue in mouse
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    Chuanmiao Yu, Shang Qiao, Liangjian Liu, Chengbo Liu, Yunyao Zhang, Yaguang Ren. Handheld Multispectral Photoacoustic Imaging Probe for Label-Free Lipid Detection and Imaging Performance Optimization (Invited)[J]. Laser & Optoelectronics Progress, 2025, 62(18): 1817020

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    Paper Information

    Category: Medical Optics and Biotechnology

    Received: May. 16, 2025

    Accepted: Jun. 6, 2025

    Published Online: Sep. 16, 2025

    The Author Email: Chengbo Liu (cb.liu@siat.ac.cn), Yunyao Zhang (yunyaozhang@nwu.edu.cn), Yaguang Ren (yg.ren@siat.ac.cn)

    DOI:10.3788/LOP251235

    CSTR:32186.14.LOP251235

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