Light-sheet microscopy has become a pivotal tool in life sciences, offering benefits such as high-throughput 3D tomography and suitability for long-term in vivo imaging. Despite these advantages, the impact of light scattering on imaging performance across different optical microscopes in scattering media remains poorly understood. This study addresses this knowledge gap by considering the electric field at the back focal plane of objective. It employs the fractal propagation method to derive the light propagation in heterogeneous scattering media and utilizes the adjoint method to develop a dual objective simulation architecture for optical microscopy. By integrating various scanning and detection strategies from different optical microscopes, the image formation process was elaborated, facilitating three-dimensional imaging simulations across four distinct types of optical microscopes. The study reveals that the capability of light-sheet microscopy to retain image quality is correlated with the confocal properties of the microscope and the thickness of the light sheet, rather than the size of the slit and the detection end exhibits greater susceptibility to scattering effects than the illumination end.