[2] [2] PANAY N, ANDERSON R A, BENNIE A, et al. Evidence-based guideline: premature ovarian insufficiency[J]. Hum Reprod Open, 2024, 2024(4): hoae065. DOI: 10.1093/hropen/hoae065.

[4] [4] LI M, ZHU Y, WEI J, et al. The global prevalence of premature ovarian insufficiency: a systematic review and meta-analysis[J]. Climacteric, 2023, 26(2): 95-102. DOI: 10.1080/13697137.2022.2153033.

[6] [6] RUTH K S, DAY F R, HUSSAIN J, et al. Genetic insights into biological mechanisms governing human ovarian ageing[J]. Nature, 2021, 596(7872): 393-397. DOI: 10.1038/s41586-021-03779-7.

[8] [8] HUANG C Z, ZHAO S M, YANG Y J, et al. TP63 gain-of-function mutations cause premature ovarian insufficiency by inducing oocyte apoptosis[J]. J Clin Invest, 2023, 133(5): e162315. DOI: 10.1172/JCI162315.

[9] [9] FANOURIAKIS A, KOSTOPOULOU M, CHEEMA K, et al. 2019 Update of the Joint European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association (EULAR/ERA-EDTA) recommendations for the management of lupus nephritis[J]. Ann Rheum Dis, 2020, 79(6): 713-723. DOI: 10.1136/annrheumdis-2020-216924.

[10] [10] QIN X S, ZHAO Y, ZHANG T Y, et al. TrkB agonist antibody ameliorates fertility deficits in aged and cyclophosphamide-induced premature ovarian failure model mice[J]. Nat Commun, 2022, 13(1): 914. DOI: 10.1038/s41467-022-28611-2.

[11] [11] DING C Y, ZHU L P, SHEN H, et al. Exosomal miRNA-17-5p derived from human umbilical cord mesenchymal stem cells improves ovarian function in premature ovarian insufficiency by regulating SIRT7[J]. Stem Cells, 2020, 38(9): 1137-1148. DOI: 10.1002/stem.3204.

[12] [12] LIU M Y, ZHANG D, ZHOU X W, et al. Cell-free fat extract improves ovarian function and fertility in mice with premature ovarian insufficiency[J]. Stem Cell Res Ther, 2022, 13(1): 320. DOI: 10.1186/s13287-022-03012-w.

[13] [13] MO J H, HU H, LI P D, et al. Human hair follicle-derived mesenchymal stem cells improve ovarian function in cyclophosphamide-induced POF mice[J]. Stem Cell Res Ther, 2025, 16(1): 67. DOI: 10.1186/s13287-024-04097-1.

[14] [14] BHARDWAJ J K, BIKAL P, SACHDEVA S N. Chemotherapeutic drugs induced female reproductive toxicity and treatment strategies[J]. J Biochem Mol Toxicol, 2023, 37(7): e23371. DOI: 10.1002/jbt.23371.

[15] [15] SWIGONSKA S, NYNCA A, MOLCAN T, et al. The role of lncRNAs in the protective action of tamoxifen on the ovaries of tumor-bearing rats receiving cyclophosphamide[J]. Int J Mol Sci, 2024, 25(23): 12538. DOI: 10.3390/ijms252312538.

[16] [16] YAO Y, WANG B, YU K H, et al. Nur77 ameliorates cyclophosphamide-induced ovarian insufficiency in mice by inhibiting oxidative damage and cell senescence[J]. J Ovarian Res, 2024, 17(1): 203. DOI: 10.1186/s13048-024-01532-y.

[17] [17] LANDE Y, FISCH B, TSUR A, et al. Short-term exposure of human ovarian follicles to cyclophosphamide metabolites seems to promote follicular activationin vitro[J]. Reprod Biomed Online, 2017, 34(1): 104-114. DOI: 10.1016/j.rbmo.2016.10.005.

[18] [18] YUKSEL A, BILDIK G, SENBABAOGLU F, et al. The magnitude of gonadotoxicity of chemotherapy drugs on ovarian follicles and granulosa cells varies depending upon the category of the drugs and the type of granulosa cells[J]. Hum Reprod, 2015, 30(12): 2926-2935. DOI: 10.1093/humrep/dev256.

[19] [19] DI EMIDIO G, D'AURORA M, PLACIDI M, et al. Pre-conceptional maternal exposure to cyclophosphamide results in modifications of DNA methylation in F1 and F2 mouse oocytes: evidence for transgenerational effects[J]. Epigenetics, 2019, 14(11): 1057-1064. DOI: 10.1080/15592294.2019.1631111.

[20] [20] PETRILLO S K, DESMEULES P, TRUONG T Q, et al. Detection of DNA damage in oocytes of small ovarian follicles following phosphoramide mustard exposures of cultured rodent ovariesin vitro[J]. Toxicol Appl Pharmacol, 2011, 253(2): 94-102. DOI: 10.1016/j.taap.2011.03.012.

[21] [21] AI G H, MENG M, GUO J, et al. Adipose-derived stem cells promote the repair of chemotherapy-induced premature ovarian failure by inhibiting granulosa cells apoptosis and senescence[J]. Stem Cell Res Ther, 2023, 14(1): 75. DOI: 10.1186/s13287-023-03297-5.

[22] [22] LUAN Y, EDMONDS M E, WOODRUFF T K, et al. Inhibitors of apoptosis protect the ovarian reserve from cyclophosphamide[J]. J Endocrinol, 2019, 240(2): 243-256. DOI: 10.1530/JOE-18-0370.

[23] [23] NGUYEN Q N, ZERAFA N, LIEW S H, et al. Loss of PUMA protects the ovarian reserve during DNA-damaging chemotherapy and preserves fertility[J]. Cell Death Dis, 2018, 9(6): 618. DOI: 10.1038/s41419-018-0633-7.

[24] [24] JEELANI R, KHAN S N, SHAEIB F, et al. Cyclophosphamide and acrolein induced oxidative stress leading to deterioration of metaphase Ⅱ mouse oocyte quality[J]. Free Radic Biol Med, 2017, 110: 11-18. DOI: 10.1016/j.freeradbiomed.2017.05.006.

[25] [25] CHEN Y, ZHAO Y, MIAO C Y, et al. Quercetin alleviates cyclophosphamide-induced premature ovarian insufficiency in mice by reducing mitochondrial oxidative stress and pyroptosis in granulosa cells[J]. J Ovarian Res, 2022, 15(1): 138. DOI: 10.1186/s13048-022-01080-3.

[26] [26] GONG L L, HOU J L, YANG H J, et al. Kuntai capsule attenuates premature ovarian insufficiency by activating the FOXO3/SIRT5 signaling pathway in mice: A comprehensive study using UHPLC-LTQ-Orbitrap and integrated pharmacology[J]. J Ethnopharmacol, 2024, 322: 117625. DOI: 10.1016/j.jep.2023.117625.

[27] [27] PACELLA-INCE L, ZANDER-FOX D L, LANE M. Mitochondrial SIRT5 is present in follicular cells and is altered by reduced ovarian reserve and advanced maternal age[J]. Reprod Fertil Dev, 2014, 26(8): 1072-1083. DOI: 10.1071/RD13178.

[28] [28] CASTRILLON D H, MIAO L L, KOLLIPARA R, et al. Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a[J]. Science, 2003, 301(5630): 215-218. DOI: 10.1126/science.1086336.

[29] [29] KUMAR S, LOMBARD D B. Functions of the sirtuin deacylase SIRT5 in normal physiology and pathobiology[J]. Crit Rev Biochem Mol Biol, 2018, 53(3): 311-334. DOI: 10.1080/10409238.2018.1458071.

[30] [30] WANG Y F, ZHU Y B, XING S G, et al. SIRT5 prevents cigarette smoke extract-induced apoptosis in lung epithelial cellsviadeacetylation of FOXO3[J]. Cell Stress Chaperones, 2015, 20(5): 805-810. DOI: 10.1007/s12192-015-0599-7.