[1] [1] YANG S, SONG Y, HU Y, et al. Multifaceted roles of copper ions in anticancer nanomedicine[J]. Advanced Health-care Materials, 2023, 12(23): 2300410.

[2] [2] HANAHAN D. Hallmarks of cancer: new dimensions[J]. Cancer Discovery, 2022, 12(1): 31-46.

[5] [5] ZHANG M, SONG R, LIU Y, et al. Calcium-overload-mediated tumor therapy by calcium peroxide nanoparticles[J]. Chem, 2019, 5(8): 2171-2182.

[6] [6] DU Y, ZHANG R, YANG J, et al. A “closed-loop” therapeutic strategy based on mutually reinforced ferroptosis and im-munotherapy[J]. Advanced Functional Materials, 2022, 32(13): 2111784.

[7] [7] DING B, CHEN H, TAN J, et al. ZIF-8 nanoparticles evoke pyroptosis for high-efficiency cancer immunotherapy[J]. Angew Chem Int Ed Engl, 2023, 62(10): e202215307.

[8] [8] LIU Y, ZHEN W, WANG Y, et al. Na2S2O8 nanoparticles trigger antitumor immunotherapy through reactive oxygen species storm and surge of tumor osmolarity[J]. Journal of the American Chemical Society, 2020, 142(52): 21751-21757.

[9] [9] LEE D, HA J, KANG M, et al. Strategies of perturbing ion homeostasis for cancer therapy[J]. Advanced Therapeutics, 2022, 5(2): 2100189.

[10] [10] WANG C, YANG X, DONG C, et al. Cu-related agents for cancer therapies[J]. Coordination Chemistry Reviews, 2023, 487: 215156.

[11] [11] WEI C, FU Q. Cell death mediated by nanotechnology via the cuproptosis pathway: a novel horizon for cancer therapy[J]. View, 2023, 4(3): 230001.

[13] [13] NIU B, LIAO K, ZHOU Y, et al. Application of glutathione depletion in cancer therapy: enhanced ros-based therapy, ferroptosis, and chemotherapy[J]. Biomaterials, 2021, 277: 121110.

[14] [14] GODET I, SHIN Y J, JU J A, et al. Fate-mapping post-hypoxic tumor cells reveals a ros-resistant phenotype that pro-motes metastasis[J]. Nature Communications, 2019, 10(1): 4862.

[15] [15] XIONG Y, XIAO C, LI Z, et al. Engineering nanomedicine for glutathione depletion-augmented cancer therapy[J]. Chem Soc Rev, 2021, 50(10): 6013-6041.

[16] [16] TSVETKOV P, COY S, PETROVA B, et al. Copper induces cell death by targeting lipoylated TCA cycle proteins[J]. Science, 2022, 375(6586): 1254-1261.

[17] [17] NAGAI M, VO N H, SHIN OGAWA L, et al. The oncology drug elesclomol selectively transports copper to the mitochondria to induce oxidative stress in cancer cells[J]. Free Radical Biology and Medicine, 2012, 52(10): 2142-2150.

[18] [18] ZHAO F, LIANG L, WANG H, et al. H2S-activated ion-interference therapy: a novel tumor targeted therapy based on copper-overload-mediated cuproptosis and pyroptosis[J]. Advanced Functional Materials, 2023, 33(38): 2300941.

[19] [19] LI R, ZHAO W, HAN Z, et al. Self-cascade nanozyme reactor as a cuproptosis inducer synergistic inhibition of cellular respiration boosting radioimmunotherapy[J]. Small, 2024, 20: 2306263.

[20] [20] VANDER HEIDEN M G, CANTLEY L C, THOMPSON C B. Understanding the Warburg effect: the metabolic requirements of cell proliferation[J]. Science, 2009, 324(5930): 1029-1033.

[21] [21] WU S, ZHANG K, LIANG Y, et al. Nano-enabled tumor systematic energy exhaustion via zinc (Ⅱ) interference mediated glycolysis inhibition and specific glut1 depletion[J]. Advanced Science, 2021, 9(7): 2103534.

[22] [22] ZHU J, YOU Y, ZHANG W, et al. Sensitizing cuproptosis by endogenous copper-triggered bioorthogonal nanoremodeler[J]. Nano Today, 2024, 55: 102196.

[23] [23] QIAO L, ZHU G, JIANG T, et al. Self-destructive copper carriers induce pyroptosis and cuproptosis for efficient tumor immunotherapy against dormant and recurrent tumors[J]. Advanced Materials, 2023, 36(8): 2308241.

[24] [24] HUANG Y, LIU X, ZHU J, et al. Enzyme core spherical nucleic acid that enables enhanced cuproptosis and antitumor immune response through alleviating tumor hypoxia[J]. Journal of the American Chemical Society, 2024, 146(20): 13805-13816.

[25] [25] DU C, GUO X, QIU X, et al. Self-reinforced bimetallic mito-jammer for Ca2+ overload-mediated cascade mitochondrial damage for cancer cuproptosis sensitization[J]. Advanced Science, 2024, 11(15): 2306031.

[26] [26] TIAN X, XU H, ZHOU F, et al. An intelligent cupreous nanoplatform with self-supplied H2O2 and Cu2+/Cu+ conversion to boost cuproptosis and chemodynamic combined therapy[J]. Chemistry of Materials, 2024, 36(2): 815-828.

[27] [27] HU F, HUANG J, BING T, et al. Stimulus-responsive copper complex nanoparticles induce cuproptosis for augmented cancer immunotherapy[J]. Advanced Science, 2024, 11(13): 2309388.

[28] [28] LU X, CHEN X, LIN C, et al. Elesclomol loaded copper oxide nanoplatform triggers cuproptosis to enhance antitumor immunotherapy[J]. Advanced Science, 2024, 11(18): 2309984.

[29] [29] ZHAO F, LIANG L, WANG H, et al. H2S-activated ion-interference therapy: a novel tumor targeted therapy based on copper-overload-mediated cuproptosis and pyroptosis[J]. Advanced Functional Materials, 2023, 33(38): 2202949.

[30] [30] XIAO W, QU K, ZHANG W, et al. High immunogenic cuproptosis evoked byin situsulfidation-activated pyroptosis for tumor-targeted immunotherapy of colorectal cancer[J]. Small Science, 2024, 4(3): 2300164.

[31] [31] CHAN L, LIU Y, CHEN M, et al. Cuproptosis-driven enhancement of thermotherapy by sequentially response Cu2-xSe via copper chemical transition[J]. Advanced Functional Materials, 2023, 33(33): 2302054.

[32] [32] ZHANG J, PENG L, HAO Y, et al. Biodegradable CuMo04 nanodots with multienzyme activities for multimodal treatment of tumor[J]. Advanced Healthcare Materials, 2023, 12(22): 2300167.

[33] [33] SONG Y, ZHAN G, ZHOU S F. Design of near infrared light-powered copper phyllosilicate nanomotors for cuproptosis-based synergistic cancer therapy[J]. Advanced Functional Materials, 2024, 34(18): 2314568.

[34] [34] ZHOU J, YU Q, SONG J, et al. Photothermally triggered copper payload release for cuproptosis-promoted cancer synergistic therapy[J]. Angewandte Chemie International Edition, 2023, 62(12): 202213922.

[35] [35] GUO B, YANG F, ZHANG L, et al. Cuproptosis induced by ros responsive nanoparticles with elesclomol and copper combined with alphapd-l1 for enhanced cancer immunotherapy[J]. Advanced Materials, 2023, 35(22): e2212267.

[36] [36] XU Y, LIU S Y, ZENG L, et al. An enzyme-engineered nonporous copper (I) coordination polymer nanoplatform for cuproptosis-based synergistic cancer therapy[J]. Advanced Materials, 2022, 34(43): 2204733.

[37] [37] BIAN Y, LIU B, DING B, et al. An enzyme-engineered coppery nanozyme for high-efficiency mild photothermal/chemodynamic/starvation therapy through self-reinforcing cancer energy metabolism regulation[J]. Advanced Functional Materials, 2024: 2313853.