Chinese Journal of Lasers, Volume. 45, Issue 8, 807001(2018)

Swept Source Optical Coherence Tomography System for Transdermal Drug Delivery Imaging by Microneedles

Song Siyu1,2, Li Zhongliang1,2、*, Gao Yunhua2,3, Yu Junjie1, Nan Nan1, Wang Xuan1,2, Yuan Chunxiao1, and Wang Xiangzhao1,2
Author Affiliations
  • 1[in Chinese]
  • 2[in Chinese]
  • 3[in Chinese]
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    Figures & Tables(7)
    (a) Intensity distribution in cross-section; (b) one-dimensional horizontal intensity distribution
    Schematic of high-quality Bessel beam generated by CDG
    Schematic of SSOCT system (the solid line represents the optical signal and the dotted line represents the electrical signal)
    Flow chart of data processing algorithm
    (a) Axial point spread function; (b) image of 3 μm microbeads; (c)-(e) lateral point spread functions
    Schematic of a microneedle array and its geometrical shape
    (a) Image of microneedle array inserted into the skin; (b) OCT image before inserting the microneedle; (c)-(e) OCT images of microneedle array inserted into the skin for 0, 30, 60 min, respectively; (f) OCT image after removing the microneedle base plate
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    Song Siyu, Li Zhongliang, Gao Yunhua, Yu Junjie, Nan Nan, Wang Xuan, Yuan Chunxiao, Wang Xiangzhao. Swept Source Optical Coherence Tomography System for Transdermal Drug Delivery Imaging by Microneedles[J]. Chinese Journal of Lasers, 2018, 45(8): 807001

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    Paper Information

    Category: biomedical photonics and laser medicine

    Received: Feb. 2, 2018

    Accepted: --

    Published Online: Aug. 11, 2018

    The Author Email: Zhongliang Li (lizhongliang@siom.ac.cn)

    DOI:10.3788/CJL201845.0807001

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