[1] [1] HUANG K X, XIA L Q, ZHANG Y M, et al. Recent advances in the biochemistry of spinosyns[J]. Applied Microbiology and Biotechnology, 2009, 82(1): 13-23.

[2] [2] SMITH R J, CHEN Y T, LAFLEUR C I, et al. Effect of sublethal concentrations of the bioinsecticide spinosyn treatment of Trichoplusia ni eggs on the caterpillar and its parasitoid, Trichogramma brassicae[J]. Pest Management Science, 2024, 80(6): 2965-2975.

[3] [3] TAO H, ZHANG Y C, DENG Z X, et al. Strategies for enhancing the yield of the potent insecticide spinosad in actinomycetes[J]. Biotechnology Journal, 2019, 14(1): e1700769.

[4] [4] YAN Y S, XIA H Y. Recent advances in the research of milbemycin biosynthesis and regulation as well as strategies for strain improvement[J]. Archives of Microbiology, 2021, 203(10): 5849-5857.

[5] [5] LI S, LI Z, PANG S, et al. Coordinating precursor supply for pharmaceutical polyketide production in Streptomyces[J]. Current Opinion in Biotechnology, 2021, 69: 26-34.

[6] [6] DENG C, LV X, LI J, et al. Synergistic improvement of N-acetylglucosamine production by engineering transcription factors and balancing redox cofactors[J]. Metabolic Engineering, 2021, 67: 330-346.

[7] [7] FORDJOUR E, ADIPAH F K, ZHOU S, et al. Metabolic engineering of Escherichia coli BL21 (DE3) for de novo production of L-DOPA from D-glucose[J]. Microbial Cell Factories, 2019,18(1): 74.

[8] [8] CAO L, LIU Y, SUN L, et al. Enhanced triacylglycerol metabolism contributes to the efficient biosynthesis of spinosad in Saccharopolyspora spinosa[J]. Synthetic and Systems Biotechnology, 2024, 9(4): 809-819.

[9] [9] CAO L, ZHU Z R, QIN H, et al. Effects of a pirin-like protein on strain growth and spinosad biosynthesis in Saccharopolyspora spinosa[J]. Applied Microbiology and Biotechnology, 2023,107(17): 5439-5451.

[10] [10] LIU Z D, ZHU Z R, TANG J L, et al. RNA-Seq-Based transcriptomic analysis of Saccharopolyspora spinosa revealed the critical function of PEP phosphonomutase in the replenishment pathway[J]. Journal of Agricultural and Food Chemistry, 2020, 68(49): 14660-14669.

[11] [11] LIU Z D, XIAO J, TANG J L, et al. Effects of acuC on the growth development and spinosad biosynthesis of Saccharopolyspora spinosa[J]. Microbial Cell Factories, 2021, 20(1): 141.

[12] [12] DUAN Y H, FANG F, MU X, et al. Exploration of Streptomyces fradiae J1-021 as a potential host for the heterologous production of spinosad[J]. Journal of Agricultural and Food Chemistry, 2024, 72(16): 8983-8992

[13] [13] AN Z H, TAO H, WANG Y, et al. Increasing the heterologous production of spinosad in Streptomyces albus J1074 by regulating biosynthesis of its polyketide skeleton[J]. Synthetic and Systems Biotechnology, 2021, 6(4): 292-301.

[14] [14] ZHAO C, HUANG Y, GUO C, et al. Heterologous expression of spinosyn biosynthetic gene cluster in Streptomyces species is dependent on the expression of rhamnose biosynthesis genes[J]. Journal of Microbiology and Biotechnology, 2017, 27(3):190-198.

[15] [15] RANG J, LI Y L, CAO L, et al. Deletion of a hybrid NRPST1PKS biosynthetic gene cluster via Latour gene knockout system in Saccharopolyspora pogona and its effect on butenyl-spinosyn biosynthesis and growth development[J]. Microbial Biotechnology, 2021, 14(6): 2369-2384.

[16] [16] ZHAO X L, HUSSAIN M H, MOHSIN A, et al. Mechanistic insight for improving butenyl-spinosyn production through combined ARTP/UV mutagenesis and ribosome engineering in Saccharopolyspora pogona[J]. Frontiers in Bioengineering and Biotechnology, 2024, 11: 1329859.

[17] [17] YANG Q, LI Y L, YANG H J, et al. Proteomic insights into metabolic adaptation to deletion of metE in Saccharopolyspora spinosa[J]. Applied Microbiology and Biotechnology, 2015, 99(20):8629-8641.

[18] [18] HE H C, TANG J L, CHEN J M, et al. Flaviolin-like gene cluster deletion optimized the butenyl-spinosyn biosynthesis route in Saccharopolyspora pogona[J]. ACS Synthetic Biology, 2021,10(10): 2740-2752.

[19] [19] RANG J, CAO L, SHUAI L, et al. Promoting butenyl-spinosyn production based on omics research and metabolic network construction in Saccharopolyspora pogona[J]. Journal of Agricultural and Food Chemistry, 2022, 70(11): 3557-3567

[20] [20] ZHU D, LIU Y, YANG H, et al. Combinatorial strain improvement and bioprocess development for efficient production of -poly-L-lysine in Streptomyces albulus[J]. Bioresource Technology, 2024, 407: 131123.

[21] [21] LEE N, HWANG S, KIM W, et al. Systems and synthetic biology to elucidate secondary metabolite biosynthetic gene clusters encoded in Streptomyces genomes[J]. Natural Product Reports, 2021, 38(7): 1330-1361.

[22] [22] LUO Y S, DING X Z, XIA L Q, et al. Comparative proteomic analysis of Saccharopolyspora spinosa SP06081 and PR2 strains reveals the differentially expressed proteins correlated with the increase of spinosad yield[J]. Proteome Science, 2011, 9(1): 40.

[23] [23] YANG Q, DING X Z, LIU X M, et al. Differential proteomic profiling reveals regulatory proteins and novel links between primary metabolism and spinosad production in Saccharopolyspora spinosa[J]. Microbial Cell Factories, 2014, 13(1): 27.

[24] [24] BRIDGET A F, NGUYEN C T, MAGAR R T, et al. Increasing production of spinosad in Saccharopolyspora spinosa by metabolic engineering[J]. Biotechnology and Applied Biochemistry, 2023, 70(3): 1035-1043.

[25] [25] WAN M Y, PENG C, DING W X, et al. Calcium-phosphate combination enhances spinosad production in Saccharopolyspora spinosa via regulation of fatty acid metabolism[J]. Applied Biochemistry and Biotechnology, 2022, 194(6): 2528-2541.

[26] [26] ZHANG Y P, LIU X M, YIN T, et al. Comparative transcriptomic analysis of two Saccharopolyspora spinosa strains reveals the relationships between primary metabolism and spinosad production[J]. Scientific Reports, 2021, 11(1): 14779.