NIR Spectroscopic Study and Staging Diagnosis of Osteoarthritic Articular Cartilage

Juan-juan FU; Dan-ying MA; Jin-lan TANG; Yi-lin BAO; Yuan ZHAO; Lin-wei SHANG; Jian-hua YIN

doi:10.3964/j.issn.1000-0593(2021)09-2770-06

Spectroscopy and Spectral Analysis, Volume. 41, Issue 9, 2770(2021)

NIR Spectroscopic Study and Staging Diagnosis of Osteoarthritic Articular Cartilage

Juan-juan FU^*, Dan-ying MA, Jin-lan TANG, Yi-lin BAO, Yuan ZHAO, Lin-wei SHANG, and Jian-hua YIN^*;

Author Affiliations

Department of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 211106, China

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Figures & Tables(7)

Fig. 1. The near-infrared average spectra of healthy and multi-stage OA tissues at SZ(a), TZ(b), DZ(c), respectively

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Fig. 2. The absorbance ratios of the 4 610 to 4 898 cm^-1 band (a), the complex to 4 898 cm^-1 band (b), the complex to 4 610 cm^-1 band (c) of healthy and multi-stage OA tissues at different depths (SZ, TZ, DZ), respectively

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Fig. 3. The scatter plots of the first 3 principal factors on the SZ NIR spectra of healthy and OA tissues with preprocess of BC(a), 1^st-2-21SG (b) and 2^nd-3-25SG (c), respectively

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Table 1. Sample information of horizontal section of articular cartilage

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Table 1. Sample information of horizontal section of articular cartilage

分组	实验犬编号	软骨切块编号	切片深度 /μm	切片数量 /个
OA-3M	Y1	1	50~800	16
		2	50~700	14
	Y2	3	100~1 050	20
		4	100	1
	Y3	5	50~550	11
		6	50~700	14
OA-7M	Y4	7	50~950	19
		8	50~950	19
	Y5	9	50~900	18
	Y6	10	50~700	14
		11	100	1
健康	Y7	12	50~850	17
		13	50~1 050	21
		14	50~600	12
	Y8	15	50~450	9
		16	50	1
		17	50	1
	Y9	18	50~500	10

Table 2. Fisher discrimination of healthy and OA tissues with different pretreatment methods of NIR spectroscopy
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Table 2. Fisher discrimination of healthy and OA tissues with different pretreatment methods of NIR spectroscopy
预处理方式 SZ识别
率/% TZ识别
率/% DZ识别
率/%
BC 80 76.2 71.3
初始案例 1^st-2-21SG 95 85.7 73.8
2^nd-3-25SG 85 76.2 55.7
BC 50 71.4 67.2
交叉验证 1^st-2-21SG 90 85.7 71.8
2^nd-3-25SG 70 42.9 54.0

Table 3. PCA-FDA significant test results of NIR spectral data at SZ, TZ and DZ with preprocess of 1^st-2-21SG
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Table 3. PCA-FDA significant test results of NIR spectral data at SZ, TZ and DZ with preprocess of 1^st-2-21SG
组别主因子数PC/个 Wilk's lambda sig.
SZ 5 0.345 0.006
TZ 5 0.366 0.005
DZ 5 0.772 0.000

Table 4. PCA-FDA of NIR spectral training and prediction sets of healthy and multi-stage OA cartilage (SZ, TZ, DZ)

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Table 4. PCA-FDA of NIR spectral training and prediction sets of healthy and multi-stage OA cartilage (SZ, TZ, DZ)

类别		光谱数据	初始判别结果			交叉判别结果			识别率/%
类别		光谱数据	健康组	OA-3M	OA-7M	健康组	OA-3M	OA-7M	初始案例	交叉验证
	健康组	6	6			6
训练集	OA-3M	5		4	1	1	3	1	93.8	87.5
	OA-7M	5			5			5
	健康组	3	3
预测集	OA-3M	2		1	1				87.5
	OA-7M	3			3

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Juan-juan FU, Dan-ying MA, Jin-lan TANG, Yi-lin BAO, Yuan ZHAO, Lin-wei SHANG, Jian-hua YIN. NIR Spectroscopic Study and Staging Diagnosis of Osteoarthritic Articular Cartilage[J]. Spectroscopy and Spectral Analysis, 2021, 41(9): 2770

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Paper Information

Category: Research Articles

Received: Jul. 19, 2020

Accepted: --

Published Online: Oct. 29, 2021

The Author Email: FU Juan-juan (15951993619@163.com)

DOI:10.3964/j.issn.1000-0593(2021)09-2770-06

Topics

laser devices and laser physics

Lasers and Laser Optics

Laser physics

laser manufacturing

Instrumentation, Measurement and Metrology

Table 1. Sample information of horizontal section of articular cartilage

Table 1. Sample information of horizontal section of articular cartilage

Table 2. Fisher discrimination of healthy and OA tissues with different pretreatment methods of NIR spectroscopy

Table 2. Fisher discrimination of healthy and OA tissues with different pretreatment methods of NIR spectroscopy

Table 3. PCA-FDA significant test results of NIR spectral data at SZ, TZ and DZ with preprocess of 1st-2-21SG

Table 3. PCA-FDA significant test results of NIR spectral data at SZ, TZ and DZ with preprocess of 1st-2-21SG

Table 4. PCA-FDA of NIR spectral training and prediction sets of healthy and multi-stage OA cartilage (SZ, TZ, DZ)

Table 4. PCA-FDA of NIR spectral training and prediction sets of healthy and multi-stage OA cartilage (SZ, TZ, DZ)

Table 3. PCA-FDA significant test results of NIR spectral data at SZ, TZ and DZ with preprocess of 1^st-2-21SG

Table 3. PCA-FDA significant test results of NIR spectral data at SZ, TZ and DZ with preprocess of 1^st-2-21SG