Fig. 1. System diagram of PS-SD-OCT

Fig. 2. Typical PS-OCT images of normal mouse brain in coronal sections. (a) En-face images of edge area; (b) B-scan images of edge area; (c) en-face images of center area; (d) B-scan images of center area. Intensity images, phase retardation images, and optic axis images are shown from left to right

Fig. 3. OCT en-face images of normal mouse brain in coronal sections. (a) Photograph of mouse brain; (b) HE stained histological section of mouse brain; (c) intensity image; (d) phase retardation image; (e) optic axis image

Fig. 4. OCT en-face images of glioma mouse brain in coronal sections with tumor infiltration in both encephalic regions. (a) Fluorescence image; (b) photograph of mouse brain; (c) intensity image; (d) phase retardation image; (e) optic axis image

Fig. 5. OCT en-face images of glioma mouse brain in coronal sections with tumor infiltration in one encephalic region. (a) Fluorescence image; (b) photograph of mouse brain; (c) intensity image; (d) phase retardation image; (e) optic axis image

Fig. 6. Analysis of optic axis information of mouse brain in coronal sections. (a) Optic axis image in normal region; (b) optic axis image in glioma region; (c) histogram of optic axis; (d) optic axis standard deviation image in normal region; (e) optic axis standard deviation image in glioma region; (f) box plot of optic axis standard deviation

Fig. 7. Relationship between spatial window size and optic axis standard deviation. (a) Box plot of optic axis standard deviation in normal region; (b) box plot of optic axis standard deviation in glioma region