NUCLEAR TECHNIQUES, Volume. 46, Issue 3, 030301(2023)

Preparation and biodistribution study of 131I-BEV-PTX-SPIONs

Faquan JI1, Anping JI1, Jie ZHANG1, Ling BO1, Qingsong JIAO1, Ning QI2, Dongsheng ZHANG2, and Minghua DU1、*
Author Affiliations
  • 1Department of Nuclear Medicine, The Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210029, China
  • 2College of Clinical Medicine, Southeast University, Nanjing 210009, China
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    Figures & Tables(7)
    Synthesis procedure of 131I-BEV-PTX-SPIONs
    TEM pattern of nanoparticle size (a) BEV-PTX-SPIONs (170 nm), (b) 131I-BEV-PTX-SPIONs (220 nm)
    PTX release curve of 131I-BEV-PTX-SPIONs in saline
    Uptake of 131I and 131I-BEV-PTX-SPIONs in A549 cell
    SPECT image of nude mice (a) 2 h, (b) 6 h, (c) 12 h, (d) 24 h, (e) 48 h
    • Table 1. Distribution of 131I-BEV-PTX-SPIONs in nude mice (x¯±s, n=3)

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      Table 1. Distribution of 131I-BEV-PTX-SPIONs in nude mice (x¯±s, n=3)

      器官 Organ

      注射后不同时间各器官的放射性摄取率

      Radioactive uptake rate of various organs at different time after injection / %ID·g-1

      单靶向组 Single targeting group双靶向组 Dual targeting group
      2 h6 h12 h24 h48 h2 h6h12 h24 h48 h
      血 Blood3.90±0.283.35±0.532.97±0.291.97±0.170.40±0.063.89±0.193.17±0.162.84±0.101.94±0.060.39±0.04
      肿瘤 Tumour1.51±0.221.75±0.273.72±0.232.82±0.171.97±0.141.88±0.222.32±0.23a4.95±0.59a3.71±0.36a2.63±0.19b
      肌肉 Muscle1.27±0.071.03±0.040.94±0.050.63±0.010.37±0.011.14±0.111.01±0.060.95±0.040.64±0.040.34±0.01
      脑 Brain1.67±0.031.41±0.091.21±0.140.65±0.040.39±0.011.54±0.051.33±0.111.21±0.150.60±0.030.34±0.07
      甲状腺 Thyroid1.66±0.201.61±0.071.20±0.100.47±0.040.32±0.031.61±0.131.54±0.041.10±0.120.49±0.040.23±0.04
      肺 Lung3.36±0.213.24±0.142.19±0.130.90±0.070.23±0.073.38±0.183.22±0.232.19±0.030.86±0.050.18±0.06
      心脏 Myocardium2.74±0.112.25±0.281.13±0.100.68±0.050.22±0.042.75±0.172.20±0.311.21±0.050.65±0.040.23±0.02
      肝 Liver10.64±1.398.41±2.166.07±1.854.20±0.311.64±0.1310.47±1.728.26±2.095.87±1.403.84±0.171.68±0.17
      脾 Spleen5.39±1.464.88±0.573.93±0.702.61±0.080.98±0.075.19±1.544.71±0.983.94±0.362.54±0.130.86±0.05
      胃 Stomach3.14±0.582.41±0.882.00±0.160.63±0.210.20±0.052.84±0.522.34±0.721.96±0.060.60±0.180.24±0.05
      肠 Intestines2.65±0.232.05±0.211.99±0.331.48±0.500.61±0.102.45±0.201.95±0.291.91±0.421.34±0.410.52±0.01
      肾 Kidney5.09±2.373.98±2.283.55±1.641.20±0.700.61±0.064.88±2.064.25±2.763.44±1.411.23±0.720.67±0.05
      股骨 Femur2.04±0.331.46±0.181.32±0.040.86±0.080.41±0.022.04±0.151.58±0.091.21±0.030.90±0.190.50±0.19
      性腺 Gonad1.61±0.021.52±0.101.10±0.130.44±0.080.23±0.041.51±0.321.11±0.191.07±0.060.41±0.040.21±0.04
      TN比 Ratios of target to nontarget1.19±0.121.70±0.273.95±0.324.48±0.245.32±0.331.66±0.352.30±0.26a5.19±0.47a5.76±0.26b7.80±0.50b
    • Table 2. Radioactive counts of 131I-BEV-PTX-SPIONs in nude mice (x¯±s, n=3)

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      Table 2. Radioactive counts of 131I-BEV-PTX-SPIONs in nude mice (x¯±s, n=3)

      部位 Locality2 h6 h12 h24 h48 h
      肿瘤 Tumour381.67±30.62482.67±29.37980.67±19.55789.00±11.00506.67±7.57
      肌肉 Muscle274.33±27.79226.67±23.12195.67±12.01139.00±8.5465.67±2.08
      TN比 Ratios of target to nontarget1.41±0.242.15±0.335.03±0.415.69±0.277.72±0.20
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    Faquan JI, Anping JI, Jie ZHANG, Ling BO, Qingsong JIAO, Ning QI, Dongsheng ZHANG, Minghua DU. Preparation and biodistribution study of 131I-BEV-PTX-SPIONs[J]. NUCLEAR TECHNIQUES, 2023, 46(3): 030301

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    Paper Information

    Category: Research Articles

    Received: Oct. 19, 2022

    Accepted: --

    Published Online: Apr. 17, 2023

    The Author Email:

    DOI:10.11889/j.0253-3219.2023.hjs.46.030301

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