Fig. 1. Ultraviolet-visible absorption spectra of gold nanoparticles and BRCA1 gold-nanoparticle-based molecular beacons

Fig. 2. TEM images. (a) Gold nanoparticles; (b) BRCA1 gold-nanoparticle-based molecular beacon

Fig. 3. Hybridization of BRCA1 gold-nanoparticle-based molecular beacon and complementary DNA

Fig. 4. Relationship between fluorescence intensity of BRCA1 gold-nanoparticle-based molecular beacon and target-sequence concentration

Fig. 5. Stability of BRCA1 gold-nanoparticle-based molecular beacon

Fig. 6. Fluorescence intensities of BRCA1 gold-nanoparticle- based molecular beacons under different pH

Fig. 7. Cytotoxicity of BRCA1 gold-nanoparticle- based molecular beacon

Fig. 8. Confocal microscopy imagings of BRCA1 gold-nanoparticle-based molecular beacon in BGC823 and BGC823/DDP. (a) BGC823, bright field image; (b) BGC823, fluorescence image; (c) BGC823/DDP, bright field image; (d) BGC823/DDP, fluorescence image

Fig. 9. Fluorescence intensities of BRCA1 gold-nanoparticle-based molecular beacon in BGC823 and BGC823/DDP

Fig. 10. Relative expression of BRCA1 mRNA in BGC823 and BGC823/DDP