[1] [1] ZHENG Y, HOUSTON K D. Glucose-dependent GPER1 expression modulates tamoxifen-induced IGFBP-1 accumulation［J］. Journal of Molecular Endocrinology, 2019, 63(2): 103-112.

[2] [2] Haumann I, Sturm M A, Anst?tz M, et al. GPER1 signaling initiates migration of female V-SVZ-derived cells［J］. iScience, 2020, 23(5): 101077.

[3] [3] Filardo E J, Quinn J A, Frackelton A R, et al. Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis［J］. Molecular Endocrinol, 2002, 16(1): 70-84.

[4] [4] VIVACQUA A. GPER1 and microRNA: two players in breast cancer progression［J］. International Journal of Molecular Science, 2020, 22(1): 98.

[5] [5] Xu E, Xia X, Jiang C, et al. GPER1 silencing suppresses the proliferation, migration, and invasion of gastric cancer cells by inhibiting PI3K/AKT-mediated EMT［J］. Frontiers in Cell and Developmental Biology, 2020, 8: 591239.?

[6] [6] Rigiracciolo D C, Santolla M F, Lappano R, et al. Focal adhesion kinase (FAK) activation by estrogens involves GPER in triple-negative breast cancer cells［J］. Journal of Experimental & Clinical Cancer Research, 2019, 38(1): 58.?

[7] [7] De Marco P, Lappano R, De Francesco E M, et al. GPER signaling in both cancer-associated fibroblasts and breast cancer cells mediates a feedforward IL1β/IL1R1 response［J］. Science Reports, 2016, 6: 24354.?

[8] [8] Natale C A, Li J, Zhang J, et al. Activation of G protein-coupled estrogen receptor signaling inhibits melanoma and improves response to immune checkpoint blockade［J］. Elife, 2018, 7: e31770.?

[9] [9] Cortes E, Sarper M, Robinson B, et al. GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment［J］. EMBO Reports, 2019, 20(1): e46556.?

[10] [10] Oh J J, Shivakumar M, Miller J, et al. An exome-wide rare variant analysis of Korean men identifies three novel genes predisposing to prostate cancer［J］. Scientific Reports, 2019, 9(1): 17173.

[11] [11] Pal U, Ghosh S, Limaye A M. DNA methylation in the upstream CpG island of the GPER locus and its relationship with GPER expression in colon cancer cell lines［J］. Molecular Biology Reports, 2020, 47(10): 7547-7555.

[12] [12] Feng G, Cai J, Huang Y, et al. G-protein-coupled estrogen receptor 1 promotes gender disparities in hepatocellular carcinoma via modulation of SIN1 and mTOR complex 2 activity［J］. Molecular Cancer Research, 2020, 18(12): 1863-1875.

[13] [13] Pepermans R A, Sharma G, Prossnitz E R. G protein-coupled estrogen receptor in cancer and stromal cells: functions and novel therapeutic perspectives［J］. Cells, 2021, 10(3): 672.?

[14] [14] Notas G, Kampa M, Castanas E. G protein-coupled estrogen receptor in immune cells and its role in immune-related diseases［J］. Frontiers in Endocrinology (Lausanne), 2020, 11: 579420.

[15] [15] Sayers E W, Beck J, Bolton E E, et al. Database resources of the national center for biotechnology information［J］. Nucleic Acids Research, 2021, (1): 10-17.

[16] [16] Duvaud S, Gabella C, Lisacek F, et al. Expasy, the swiss bioinformatics resource portal, as designed by its users［J］. Nucleic Acids Research, 2021, 49(1): 216-227.

[17] [17] Armenteros J J, Tsirigos K D, S?nderby C K, et al. SignalP 5.0 improves signal peptide predictions using deep neural networks［J］. Nature Biotechnology, 2019, 37(4): 420-423.

[18] [18] Chen Y, Yu P, Luo J, et al. Secreted protein prediction system combining CJ-SPHMM, TMHMM, and PSORT［J］. Mammal Genome, 2003, 14(12): 859-865.

[19] [19] Buchan D, Jones D T. The PSIPRED protein analysis workbench: 20 years on［J］. Nucleic Acids Research, 2019, 47(1): 402-407.

[20] [20] Szklarczyk D, Gable A L, Nastou K C, et al. The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene/measurement sets［J］. Nucleic Acids Research, 2021, 49(1): 605-612.

[21] [21] Tang Z, Li C, Kang B, et al. GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses［J］. Nucleic Acids Research, 2017, 45(1): 98-102.

[22] [22] Yang S, Yin Z, Zhu G. A review of the functions of G protein-coupled estrogen receptor 1 in vascular and neurological aging［J］. European Journal of Pharmacology, 2021, 908: 174363.

[23] [23] Khan S U, Ahemad N, Chuah L H, et al. Sequential ligand- and structure-based virtual screening approach for the identification of potential G protein-coupled estrogen receptor-1 (GPER-1) modulators［J］. RSC Advances, 2019, 9(5): 2525-2538.

[24] [24] Hilger D, Masureel M, Kobilka B K. Structure and dynamics of GPCR signaling complexes［J］. Nature Structure＆Molecular Biology, 2018, 25(1): 4-12.

[25] [25] Schjoldager K T, Narimatsu Y, Joshi H J, et al. Global view of human protein glycosylation pathways and functions［J］. Nature Reviews Molecular Cell Biology, 2020, 21(12): 729-749.

[26] [26] Gonzalez d e, Valdivia E, Sandén C, et al. Human G protein-coupled receptor 30 is?N-glycosylated and N-terminal domain asparagine 44 is required for receptor structure and activity［J］. Bioscience Reports, 2019, 39(2): 20182436.

[27] [27] Pupo M, Bodmer A, Berto M, et al. A genetic polymorphism repurposes the G-protein coupled and membrane-associated estrogen receptor GPER to a transcription factor-like molecule promoting paracrine signaling between stroma and breast carcinoma cells［J］. Oncotarget, 2017, 8(29): 46728-46744.

[28] [28] Bilbrough T, Piemontese E, Seitz O. Dissecting the role of protein phosphorylation: a chemical biology toolbox［J］. Chemical Society Reviews, 2022, 51(13): 5691-5730.

[29] [29] Li F, Chen Q, Yang Y, et al. ESR1 as a recurrence-related gene in intrahepatic cholangiocarcinoma: a weighted gene co-expression network analysis［J］. Cancer Cell International, 2021, 21(1): 225.

[30] [30] YE Y, LI S L, WANG S Y. Construction and analysis of mRNA, miRNA, lncRNA, and TF regulatory networks reveal the key genes associated with prostate cancer［J］. PLoS One, 2018, 13(8): e0198055.

[31] [31] Choi J Y, Lee Y S, Shim D M, et al. GNAQ knockdown promotes bone metastasis through epithelial-mesenchymal transition in lung cancer cells［J］. Bone Joint Research, 2021, 10(5): 310-320.

[32] [32] Ding H, Zhang X, Su Y, et al. GNAS promotes inflammation-related hepatocellular carcinoma progression by promoting STAT3 activation［J］. Cell Molecular Biology Letter, 2020, 25: 8.

[33] [33] Englert-Golon M, Andrusiewicz M, ?bikowska A, et al. Altered expression of?ESR1,?ESR2,?PELP1?and?c-SRC?genes is associated with ovarian cancer manifestation［J］. International Journal of Molecular Science, 2021, 22(12): 6216.

[34] [34] Muroi T, Matsushima Y, Kanamori R, et al. GPR62 constitutively activates cAMP signaling but is dispensable for male fertility in mice［J］. Reproduction, 2017, 154(6): 755-764.

[35] [35] Cho J. Mechanistic insights into differential requirement of receptor dimerization for oncogenic activation of mutant EGFR and its clinical perspective［J］. BMB Reports, 2020, 53(3): 133-141.

[36] [36] Rigiracciolo D C, Santolla M F, Lappano R, et al. Focal adhesion kinase (FAK) activation by estrogens involves GPER in triple-negative breast cancer cells［J］. Journal of Experimental Clinic Cancer Research, 2019, 38(1): 58.

[37] [37] Zhang N, Sun P, Xu Y, et al. The GPER1/SPOP axis mediates ubiquitination-dependent degradation of ERα to inhibit the growth of breast cancer induced by oestrogen［J］. Cancer Letters, 2021, 498: 54-69.

[38] [38] Deng J, Wang W, Yu G, et al. MicroRNA?195 inhibits epithelial?mesenchymal transition by targeting G protein?coupled estrogen receptor 1 in endometrial carcinoma［J］. Molecular Medicine Reports, 2019, 20(5): 4023-4032.

[39] [39] Zhou H, Chen L, Lei Y, et al. Integrated analysis of tumor mutation burden and immune infiltrates in endometrial cancer［J］. Current Problem in Cancer, 2021, 45(2): 100660.