Laser & Optoelectronics Progress, Volume. 62, Issue 18, 1817012(2025)

Bloch Surface Wave Detection Technology and Its Biomedical Applications (Invited)

Shuna Li1, Yuhang Wan2、*, and Yanyu Zhao3、**
Author Affiliations
  • 1School of Innovation and Entrepreneurship, North University of China, Taiyuan 030051, Shanxi , China
  • 2School of Electronic and Information Engineering, Beihang University, Beijing 100191, China
  • 3School of Engineering Medicine, Beihang University, Beijing 100191, China
  • show less
    Figures & Tables(19)
    Transmission characteristics of the PBG structure. (a) Schematic diagram of a 1D PBG structure; (b) dispersion diagram of frequency vs. wavevector for the p-polarized light[4]
    Schematic diagrams of BSW prism coupling structures. (a) Schematic diagram of BSW prism coupling device structure[15]; (b) physical example of microfluidic device[29]; (c) schematic of the 3D-printed BSW sensing structure[30]; (d) schematic of the 3D-printed BSW mechanical structure[30]
    Schematic diagrams of BSW grating coupling structures. (a) 1D grating structure[31]; (b) circular grating structure and its SEM image[10]; (c) 2D grating structure[32]; (d) hybrid mode grating structure with added metal[34]
    Schematic diagrams of BSW fiber coupling structures. (a) BSW detection and end-face coupling structure[27]; (b) D-shaped fiber structure[26]; (c) tapered fiber structure[38]
    Schematic diagrams of BSW waveguide coupling structures. (a) Waveguide structure with a polymeric ridge on top[40]; (b) cavity-waveguide structure[43]
    Overall research structure block diagram of BSW detection technology
    Schematic diagram of BSW-enhanced fluorescence sensing detection[49]
    Schematics of BSW label-free sensing detection[52]. (a) Detection principle; (b) reflectance spectrum
    High-throughput detection results of BSW under label-free condition[59]. (a) 384-spot microarray image displayed in natural colors; (b) 96-spot microarray image displayed in pseudo-color
    Schematic diagram of multi-channel BSW sensing detection system[60]
    Experimental setup of BSW biosensing detection based on a D-shaped optical fiber[61]. (a) SEM image of the sensing structure; (b) optical properties of two dielectric materials; (c) experimental setup for optical property characterization; (d) experimental setup for biological sample detection
    Dual-mode detection of miRNA using label-free and fluorescence methods[62]. (a) Schematic diagram of sensor chip functionalization; (b) schematic of label-free detection principle; (c) schematic of fluorescence detection principle; (d) real-time monitoring of binding kinetics
    Dual-mode detection of VEGF using label-free and fluorescence methods[67]. (a) Schematic of the experimental principle; (b) photograph of the disposable BSW biosensor chip; (c) functionalized surface of the chip; (d) reflectivity map in label-free mode; (e) fluorescence detection result
    Dual-mode detection of SARS-CoV-2 antibody using label-free and fluorescence methods[68]. (a) Schematic diagram of disposable PBG chip and its microfluidic components; (b) schematic diagram of PBG chip structure
    Schematics of BSW-ARI imaging technology[73]. (a) Experimental setup; (b) schematic of ARI; (c) BFP image of BSW; (d) SEM image of nanoparticles; (e) BSW-ARI imaging result
    Comparison between traditional microscopy and BSW-enhanced microscopy[74]. (a) Reference image; (b) imaging result of traditional microscopy; (c) imaging result of BSW-enhanced microscopy; (d) magnified view of traditional microscopy image; (e) Fourier transform of traditional microscopy image; (f) Fourier transform of BSW-enhanced microscopy image; (g) magnified view of BSW-enhanced microscopy image; (h) lateral intensity profile of a single microsphere; (i) lateral intensity profile of two adjacent microspheres
    Schematic diagrams of BSW-SIM imaging technology[75]. (a) Imaging diagram; (b) diagram of energy band structure; (c) diagram of spatial frequency extension; (d) top view of PBG structure
    • Table 1. Summary of key parameters in literature on BSW biosensing detection technologies

      View table

      Table 1. Summary of key parameters in literature on BSW biosensing detection technologies

      YearAnalyteDetection methodSensitivityLimit of detectionDetection timeRef.
      2007Streptavidin/biotinLabel-free20 fg/50 fg57
      2010Biotin/DNA oligonucleotides/protein A/BSA/IgGLabel-free1840 nm/RIU10-8 RIU52
      2011ProteinLabel-free40.35 (°)/RIU1.24×10-4 RIU53
      20111-42Label-free54
      2011/2012Protein AFluorescence4649-50
      2012GlucoseFluorescence2500 nm/RIU3×10-6 RIU48
      2012BSA/DNALabel-free600 nm/RIU45 min55
      2013Biotin/IgGLabel-free56
      2013Protein GFluorescence1400 nm/RIU6.4×10-5 RIU51
      2015SubtilisinLabel-free370 pmol/L19
      2015Angiopoietin 2Label-free31.8 (°)/RIU1 μg/mL16
      2017ERBB2Label-free0.5 ng/mL45 min63
      Fluorescence0.6 ng/mL
      2017ERBB2Label-free14.5 ng/mL30 min64
      Fluorescence0.3 ng/mL
      2018IgGLabel-free31.8 (°)/RIU28 ng/mL11
      2018IgGLabel-free393 nm/RIU3.5 pg/mm²58
      2018VEGFLabel-free0.0286 pixel/(ng/mL)11.5 ng/mL30 min67
      Fluorescence460 counts/(ng/mL)0.65 ng/mL
      2019HER2/CA15-3/CA125Label-free620 fg/mL60
      2020HER2Label-free16 ng/mL65
      Fluorescence
      2020IgGLabel-free2.5 pg/mm²​59
      2021FibrinogenLabel-free10.4 pg/mm²9
      2023SARS-CoV-2Label-free2.22 AU/mL31 s68
      Fluorescence0.222 AU/mL10 min
      2023miRNALabel-free<30 min62
      Fluorescence1 ng/mL
      2024IgGLabel-free1281 nm/RIU10 fg/mL35‒45 min61
      2024HER2Label-free<16 ng/mL20 min66
      Fluorescence
    • Table 2. Summary of key parameters in literature on BSW imaging technologies

      View table

      Table 2. Summary of key parameters in literature on BSW imaging technologies

      YearImaging typeWavelength /nmDetection methodResolution /nmApplicationRef.
      2019BSW-ARI532/635Label-free~350‒380Label-free surface imaging73
      2021BSW-SIM532Fluorescence83Fluorescence super-resolution imaging74
      2022BSW-SIM488.0/532.0/632.8Fluorescence74/81/96Integrated photonics; sensors75
    Tools

    Get Citation

    Copy Citation Text

    Shuna Li, Yuhang Wan, Yanyu Zhao. Bloch Surface Wave Detection Technology and Its Biomedical Applications (Invited)[J]. Laser & Optoelectronics Progress, 2025, 62(18): 1817012

    Download Citation

    EndNote(RIS)BibTexPlain Text
    Save article for my favorites
    Paper Information

    Category: Medical Optics and Biotechnology

    Received: May. 14, 2025

    Accepted: Jun. 5, 2025

    Published Online: Sep. 15, 2025

    The Author Email: Yuhang Wan (yuhangwan@buaa.edu.cn), Yanyu Zhao (yanyuzhao@buaa.edu.cn)

    DOI:10.3788/LOP251227

    CSTR:32186.14.LOP251227

    Topics