Mueller-Matrix Characterization of Sclerosing Adenosis and Invasive Ductal Carcinoma Tissues

Jinkui Chu; Xiaohan Ding; Yongtai Chen; Bo Huang; Bing Jiang; Benda Xin

doi:10.3788/CJL240612

Chinese Journal of Lasers, Volume. 51, Issue 21, 2107203(2024)

Mueller-Matrix Characterization of Sclerosing Adenosis and Invasive Ductal Carcinoma Tissues

Jinkui Chu^1、*, Xiaohan Ding¹, Yongtai Chen^1,2, Bo Huang^3,4,5、**, Bing Jiang³, and Benda Xin¹

Author Affiliations

¹School of Mechanical Engineering, Dalian University of Technology, Dalian 116023, Liaoning , China

²Research Center for Frontier Fundamental Studies, Zhejiang Lab , Hangzhou 311121, Zhejiang , China

³Department of Pathology, Liaoning Cancer Hospital & Institute, Shenyang 110042, Liaoning , China

⁴Cancer Hospital, China Medical University, Shenyang 110042, Liaoning , China

⁵Cancer Hospital, Dalian University of Technology, Shenyang 110042, Liaoning , China

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Figures & Tables(10)

Fig. 1. Photo and schematic diagram of Mueller matrix full polarization imaging detection system

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Fig. 2. Experimental flow chart

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Fig. 3. Fibrotic interstitial regions of SA and early IDC: characterization with phase-delay vector R. (a) 3D scatter plots; (b) minimum bounding sphere diagram

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Fig. 4. Fibrotic interstitial regions of SA and early IDC: characterization with three-parameter combinations. (a)‒(b) 3D scatter plot and minimum bounding sphere diagram characterization with three-parameter combination of R-θ-ψ; (c)‒(d) 3D scatter plot and minimum bounding sphere diagram characterization with three-parameter combination of δ-θ-ψ ; (e)‒(f) 3D scatter plot and minimum bounding sphere diagram characterization with three-parameter combination of R-δ-ψ

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Fig. 5. Fibrotic interstitial regions of SA and early IDC:characterization with dichroic vector D.(a) 3D scatter plot; (b) minimum bounding sphere diagram

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Fig. 6. Nuclear regions of SA and early IDC: characterization with scattering receding vector $Δ$ . (a) 3D scatter plot; (b) minimum bounding sphere diagram

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Fig. 7. Nuclear regions of SA and early IDC: characterization with three-parameter combination of Δ‍-‍δ‍-‍θ. (a) 3D scatter plot; (b) minimum bounding sphere diagram

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Table 1. Stokes vectors of incident polarized light

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Table 1. Stokes vectors of incident polarized light

Polarization state of incident light	Stokes vector
0° linear polarization	${(\begin{matrix} \begin{matrix} 1 & 1 & 0 \end{matrix} & 0 \end{matrix})}^{T}$
45° linear polarization	${(\begin{matrix} \begin{matrix} 1 & 0 & 1 \end{matrix} & 0 \end{matrix})}^{T}$
90° linear polarization	${(\begin{matrix} \begin{matrix} 1 & - 1 & 0 \end{matrix} & 0 \end{matrix})}^{T}$
135° linear polarization	${(\begin{matrix} \begin{matrix} 1 & 0 & - 1 \end{matrix} & 0 \end{matrix})}^{T}$
Left circular polarization	${(\begin{matrix} \begin{matrix} 1 & 0 & 0 \end{matrix} & - 1 \end{matrix})}^{T}$
Right circular polarization	${(\begin{matrix} \begin{matrix} 1 & 0 & 0 \end{matrix} & 1 \end{matrix})}^{T}$

Table 2. Characterization of fibrotic interstitial regions of SA and early IDC tissues by Mueller matrix parameters

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Table 2. Characterization of fibrotic interstitial regions of SA and early IDC tissues by Mueller matrix parameters

Structural component	Mueller matrix characterization parameter		Minimum bounding sphere radius		Relative radius difference /%
Structural component	Mueller matrix characterization parameter		SA	Early IDC	Relative radius difference /%
Fibrotic interstitial region	MMPD	Negative value of R	0.3029	0.0946	68.77
		Positive value of R	0.3143	0.1811	42.38
		R-θ-ψ	0.9628	0.3723	61.33
		δ-θ-ψ	0.9628	0.3746	61.09
		R-δ-ψ	0.9615	0.3746	61.04
		$D$	0.7875	0.4442	43.59
		$Δ$	0.4487	0.5282	20.60
		$P$	0.5699	0.7008	18.68
	MMT	b-A-x	0.2121	0.1446	31.82

Table 3. Characterization of the nuclear regions of SA and early IDC tissues by Mueller matrix parameters

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Table 3. Characterization of the nuclear regions of SA and early IDC tissues by Mueller matrix parameters

Structural component	Mueller matrix characterization parameter		Minimum bounding sphere radius		Relative radius difference /%
Structural component	Mueller matrix characterization parameter		SA	early IDC	Relative radius difference /%
Nucleus	MMPD	$Δ$	0.8504	0.3626	57.36
		Δ-δ-θ	0.3151	0.1596	49.35
		D	0.3847	0.2960	23.06
		P	0.6290	0.5098	18.95
		Negative value of R	0.1282	0.1468	14.51
		Positive value of R	0.1267	0.1326	4.66
	MMT	b-A-x	0.1642	0.1426	13.15

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Jinkui Chu, Xiaohan Ding, Yongtai Chen, Bo Huang, Bing Jiang, Benda Xin. Mueller-Matrix Characterization of Sclerosing Adenosis and Invasive Ductal Carcinoma Tissues[J]. Chinese Journal of Lasers, 2024, 51(21): 2107203

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Paper Information

Category: Optical Diagnostics and Therapy

Received: Feb. 26, 2024

Accepted: May. 13, 2024

Published Online: Oct. 31, 2024

The Author Email: Chu Jinkui (chujk@dlut.edu.cn), Huang Bo (huangbo197033@163.com)

DOI:10.3788/CJL240612

CSTR:32183.14.CJL240612

Topics

laser devices and laser physics

Lasers and Laser Optics

Laser physics

laser manufacturing

Instrumentation, Measurement and Metrology