Chinese Journal of Lasers, Volume. 50, Issue 21, 2107201(2023)
Specific Identification of Breast Tumors Based on Laser-Induced Autofluorescence Spectroscopy
Figures & Tables(5)
Fig. 2. Laser-induced steady autofluorescence spectra of normal breast gland tissues and breast malignant tumor tissues. (a) Normal breast gland tissues; (b) breast malignant tumor tissues
Fig. 3. Identification effect of three fluorescence ratio methods on normal breast glands and breast malignant tumors. (a) I430/I465 fluorescence ratio method; (b) I430/I400 fluorescence ratio method; (c) 2I430/(I400+I465) fluorescence ratio method
Fig. 4. Gaussian decomposed fittings of normal breast glands and breast malignant tumors spectra. (a) Normal breast glands spectra; (b) breast malignant tumors spectra
Table 1. Spectral fitting results and corresponding fluorophores
View tableTable 1. Spectral fitting results and corresponding fluorophores
Tissue Fitting results Peak 1 Peak 2 Peak 3 Peak 4 Fluorophore Collagen+elastin NADH Flavin adenine Gland 8.8%±1.2%
389 nm±0.46 nm
18.4%±3.3%
416 nm±1.34 nm
31.4%±8.4%
465 nm±3.01 nm
41.3%±7.9%
532 nm±13.43 nm
Tumor 4.0%±0.6%
384 nm±0.31 nm
11.5%±0.9%
401 nm±1.23 nm
46.8%±6.8%
459 nm±1.20 nm
37.6%±8.0%
537 nm±18.92 nm
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Jianfeng Yan, Jiayuan Li, Xing Zhang, Jun Tan, Jinyu Fu, Caifeng Ou, Chengyun Zhang, Yunfeng Luo, Zhifeng Chen, Pusheng Zhang. Specific Identification of Breast Tumors Based on Laser-Induced Autofluorescence Spectroscopy[J]. Chinese Journal of Lasers, 2023, 50(21): 2107201
Paper Information
Category: Optical Diagnostics and Therapy
Received: Jul. 3, 2023
Accepted: Aug. 10, 2023
Published Online: Nov. 17, 2023
The Author Email: Zhifeng Chen (chenzf@gzhu.edu.cn), Pusheng Zhang (zhangpusheng@smu.edu.cn)
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