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Acta Optica Sinica, Volume. 45, Issue 4, 0417001(2025)

Photoacoustic Microscopy System Based on Hybrid Optical-Mechanical Scanning and Image Stitching

Yuxiang Lin1,2, Xiaojun Han1, Xiufeng Li1, Jinxin Tan1, Taofeng Wu1, Chengbo Liu1, and Zhiqiang Xu1、*
Author Affiliations
  • 1Institute of Scientific Instrumentation, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518000, Guangdong , China
  • 2School of Electrical and Electronic Engineering, Shanghai Institute of Technology, Shanghai 201400, China
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    Figures & Tables(7)
    Imaging system. (a) Configuration diagram of hybrid optical-mechanical PAM system (L1: f1=50 mm; L2: f2=200 mm); (b) imaging field of view; (c) image block acquisition order

    Fig. 1. Imaging system. (a) Configuration diagram of hybrid optical-mechanical PAM system (L1: f1=50 mm; L2: f2=200 mm); (b) imaging field of view; (c) image block acquisition order

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    System spatial resolution. (a) Sharp edge imaging results and original data, ESF, and LSF of the edge; (b) single-point signal of carbon filament and envelope

    Fig. 2. System spatial resolution. (a) Sharp edge imaging results and original data, ESF, and LSF of the edge; (b) single-point signal of carbon filament and envelope

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    Image processing flow

    Fig. 3. Image processing flow

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    Imaging results of carbon filament phantom. (a) 54 sub-image blocks obtained by hybrid optical-mechanical scanning; (b) fused image after image processing and stitching

    Fig. 4. Imaging results of carbon filament phantom. (a) 54 sub-image blocks obtained by hybrid optical-mechanical scanning; (b) fused image after image processing and stitching

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    Imaging results of mouse brain. (a) Stitched image; (b)(c) magnified view of the detail

    Fig. 5. Imaging results of mouse brain. (a) Stitched image; (b)(c) magnified view of the detail

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    Comparison of processing effects on sub-image blocks. (a) Original subimage block; (b) subimage block processed by median filtering and NLM algorithm based on spatial denoising; (c) processed subimage block

    Fig. 6. Comparison of processing effects on sub-image blocks. (a) Original subimage block; (b) subimage block processed by median filtering and NLM algorithm based on spatial denoising; (c) processed subimage block

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    • Table 1. Previously reported works and system parameters

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      Table 1. Previously reported works and system parameters

      Reported systemImaging patternReported imaging speed and imaging sizeReported lateral resolution /μm
      Xie et al.［17］Optical scanning2 min for 6 mm circular7.8
      Rao et al.［18］Hybrid-scanning256 s for 4 mm×8 mm3.5
      Shao et al.［25］Hybrid-scanning and stitching90 s for 6.45 mm×5.8 mm6
      Zhao et al.［26］Mechanical scanning30 min for 8 mm×8 mm5.43
      Le et al.［27］Mechanical scanning—12
      Proposed systemHybrid-scanning and stitching72 s for 3.5 mm×3.2 mm2.89
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    Yuxiang Lin, Xiaojun Han, Xiufeng Li, Jinxin Tan, Taofeng Wu, Chengbo Liu, Zhiqiang Xu. Photoacoustic Microscopy System Based on Hybrid Optical-Mechanical Scanning and Image Stitching[J]. Acta Optica Sinica, 2025, 45(4): 0417001

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    Paper Information

    Category: Medical optics and biotechnology

    Received: Nov. 15, 2024

    Accepted: Dec. 25, 2024

    Published Online: Feb. 21, 2025

    The Author Email: Xu Zhiqiang (zq.xu@siat.ac.cn)

    DOI:10.3788/AOS241761

    CSTR:32393.14.AOS241761

    Topics

    laser devices and laser physics
    Lasers and Laser Optics
    Laser physics
    laser manufacturing
    Instrumentation, Measurement and Metrology