[1] [1] GAITONDE D Y, MOORE F C, MORGAN M K. Influenza: diagnosis and treatment[J]. American Family Physician, 2019, 100(12): 751-758.

[2] [2] LI R, LIU T, LIU M,et al. Anti-influenza A virus activity of dendrobine and its mechanism of action[J]. Journal of Agricultural and Food Chemistry, 2017, 65(18): 3665-3674.

[4] [4] HUTCHINSON E C. Influenza virus[J]. Trends in Microbiology, 2018, 26(9): 809-810.

[5] [5] CHENG P, ZHAI K, HAN W,et al. Characterizing the antigenic evolution of pandemic influenza A (H1N1) pdm09 from 2009 to 2023[J]. Journal of Medical Virology, 2024; 96(5): e29657.

[6] [6] EL-SHESHENY R, BAGATO O, KANDEIL A,et al.Re-emergence of amantadine-resistant variants among highly pathogenic avian influenza H5N1 viruses in Egypt[J]. Infection, Genetics and Evolution, 2016, 46: 102-109.

[7] [7] LIN C Y, YANG Z S, WANG W H,et al.The antiviral role of galectins toward influenza A virus infection: an alternative strategy for influenza therapy[J]. Pharmaceuticals (Basel), 2021, 14(5): 490.

[8] [8] HOSSEINZADEH H, NASSIRI-ASL M. Pharmacological effects ofGlycyrrhizaspp. and its bioactive constituents: update and review[J]. Phytotherapy Research, 2015, 29(12): 1868-1886.

[9] [9] HOSSEINZADEH L, MODARRESI M, MANOOCHEHRI Y,et al.Protective effects of Glabridin against cytotoxicity and oxidative stress induced by doxorubicin in PC12 cells[J]. Journal of Reports in Pharmaceutical Sciences, 2017, 6(1): 1-12.

[10] [10] SIMMLER C, PAULI G F, CHEN S N. Phytochemistry and biological properties of Glabridin[J]. Fitoterapia, 2013, 90: 160-184.

[11] [11] AOKI F, NAKAGAWA K, KITANO M,et al.Clinical safety of licorice flavonoid oil (LFO) and pharmacokinetics of Glabridin in healthy humans[J]. Journal of the American College of Nutrition, 2007, 26(3): 209-218.

[12] [12] HSIEH M J, CHEN M K, CHEN C J,et al. Glabridin induces apoptosis and autophagy through JNK1/2 pathway in human hepatoma cells[J]. Phytomedicine, 2016, 23(4): 359-366.

[13] [13] CHEEMA H S, PRAKASH O, PAL A,et al.Glabridin induces oxidative stress mediated apoptosis like cell death of malaria parasite Plasmodium falciparum[J]. Parasitology International, 2014, 63(2): 349-358.

[14] [14] HUANG H L, HSIEH M J, CHIEN M H,et al. Glabridin mediate caspases activation and induces apoptosis through JNK1/2 and p38 MAPK pathway in human promyelocytic leukemia cells[J]. PLoS One, 2014, 9(6): e98943.

[15] [15] HSU Y L, WU L Y, HOU M F,et al. Glabridin, an isoflavan from licorice root, inhibits migration, invasion and angiogenesis of MDA-MB-231 human breast adenocarcinoma cells by inhibiting focal adhesion kinase/Rho signaling pathway[J]. Molecular Nutrition Food Research, 2011, 55(2): 318-327.

[16] [16] KIM H S, SUH K S, KO A,et al. The flavonoid Glabridin attenuates 2-deoxy-D-ribose-induced oxidative damage and cellular dysfunction in MC3T3-E1 osteoblastic cells[J]. International Journal of Molecular Medicine, 2013, 31(1): 243-251.

[17] [17] MODARRESI M, HAJIALYANI M, MOASEFI N,et al. Evaluation of the cytotoxic and apoptogenic effects of Glabridin and its effect on cytotoxicity and apoptosis induced by doxorubicin toward cancerous cells[J]. Advanced Pharmaceutical Bulletin, 2019, 9(3): 481-489.

[18] [18] ZHANG Q, QIAN D, TANG D D,et al. Glabridin fromGlycyrrhiza glabrapossesses a therapeutic role against keloid via attenuating PI3K/Akt and transforming growth factor-beta1/SMAD signaling pathways[J]. Journal of Agricultural and Food Chemistry, 2022, 70(35): 10782-10793.

[19] [19] ISLAM R, PARVES M R, PAUL A S,et al. A molecular modeling approach to identify effective antiviral phytochemicals against the main protease of SARS-CoV-2[J]. Journal of Biomolecular Structure and Dynamics, 2021, 39(9): 3213-3224.

[20] [20] CHOE J, HAR YONG P, XIANG NG Z. The efficacy of traditional medicinal plants in modulating the main protease of SARS-CoV-2 and cytokine ctorm[J]. Chemistry Biodiversity, 2022, 19(11): e202200655.

[21] [21] MIYAKAWA K, MATSUNAGA S, YAMAOKA Y,et al.Development of a cell-based assay to identify hepatitis B virusentry inhibitors targeting the sodium taurocholate cotransporting polypeptide[J]. Oncotarget, 2018, 9(34): 23681-23694.

[22] [22] RAHMAN M M, BISWAS S, ISLAM K J,et al. Antiviral phytochemicals as potent inhibitors against NS3 protease of dengue virus[J]. Computers in Biology and Medicine, 2021, 134: 104492.

[23] [23] LUO T T, LU Y, YAN S K,et al. Network pharmacology in research of Chinese medicine formula: methodology, application and prospective[J]. Chinese Journal of Integrative Medicine, 2020, 26(1): 72-80.

[27] [27] TE VELTHUIS A J, FODOR E. Influenza virus RNA polymerase: insights into the mechanisms of viral RNA synthesis[J]. Nature Reviews Microbiology, 2016, 14(8): 479-493.

[28] [28] WU Y J, FENG W W, WU Z L,et al. Prim-O-glucosylcimifugin alleviates influenza virus-induced pneumonia in mice by inhibiting the TGF-1/PI3KCD/MSK2/RELA signalling pathway[J]. Archives of Virology, 2024, 169(11): 232.

[29] [29] RAHMAN M A, SHOROBI F M, UDDIN M N,et al.Quercetin attenuates viral infections by interacting with target proteins and linked genes in chemicobiological models[J]. In Silico Pharmacology, 2022, 10(1): 17-29.

[30] [30] EIERHOFF T, HRINCIUS E R, RESCHER U,et al. The epidermal growth factor receptor (EGFR) promotes uptake of influenza A viruses (IAV) into host cells[J]. Public Library of Science Pathogens, 2010, 6(9): e1001099.

[31] [31] WANG W, WU J, ZHANG X,et al. Inhibition of influenza A virus infection by fucoidan targeting viral neuraminidase and cellular EGFR pathway[J]. Scientific Reports, 2017, 7: 40760.

[32] [32] ZHANG S, TIAN H, CUI J,et al.The c-Jun N-terminal kinase (JNK) is involved in H5N1 influenza A virus RNA and protein synthesis[J]. Archives of Virology, 2015, 161(2): 345-351.

[33] [33] WANG R, ZHU Y, ZHAO J,et al.Autophagy promotes replication of influenza A virusin vitro[J]. The Journal of Virology, 2019, 93(4): e01984-18.