To solve the problems of dissolution and surface fragmentation of Cr₁₂MoV steel, laser cladding experiments were carried out on Cr₁₂MoV steel using Al-Ni and Nd-Ni powders. The effects of Al and Nd on the macro and micro morphology, microstructure and surface properties of nickel base cladding were studied. The results show that Al can reduce the crack generation of cladding layer and reduce the hardness of cladding layer, so that the hard phase Al₂O₃ with anti-wear effect is generated in cladding layer, and the wear amount of cladding layer is reduced. The wear amount of 14% Al cladding layer is 44.5% lower than that of 2% Al cladding layer, and the optimal Al content is 14%. The grain refinement effect of Nd is obvious, and the microhardness of the coating is significantly increased. The average hardness of the coating is 36.8% higher than that of the substrate, and the optimal content of Nd is 2.5%.