As an auxiliary means of periodontal basic treatment and periodontal surgical treatment, Nd:YAG laser (neodymium-dopedyttrium-aluminium-garnetlaser) has many functions, such as tissue ablation, sterilization, hemostasis, biological stimulation and so on. It has a broad application prospect in the field of periodontal disease treatment. In this paper, the application and research progress of Nd:YAG laser in the treatment of periodontal disease are reviewed, and the working principle of Nd:YAG laser and its application in periodontal soft and hard tissues are introduced systematically, so as to better guide the application of Nd:YAG laser in clinical periodontal therapy.