Chinese Journal of Lasers, Volume. 47, Issue 2, 207022(2020)

Low Photon Count Fluorescence Lifetime Analysis Based on Alternating Descent Conditional Gradient Method

Zhang Xiao, Lin Danying, Niu Jingjing, Liu Xiongbo, Zhang Jiao, Yu Bin, Zhang Wei, and Qu Junle
Author Affiliations
  • Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, Guangdong 518060, China
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    Figures & Tables(6)
    Workflow of our ADCG-FLIM algorithm
    Statistical results of estimated lifetime versus photon counts. (a) Average error of estimated lifetime; (b) distribution width of estimated lifetime
    Statistical results of estimated lifetime versus background level. (a) Average error of estimated lifetime; (b) distribution width of estimated lifetime
    Statistical results of estimated photon counts versus background level. (a) Average error of estimated photon counts; (b) ratio of normalized photon counts distribution width to true photon counts
    Lifetime analysis results of experimental data with average photon counts 45 using different algorithms. (a) LS-FLIM; (b) ADCG-FLIM
    Lifetime analysis results using LS-FLIM when averagephoton counts of experimental data are increased to 430
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    Zhang Xiao, Lin Danying, Niu Jingjing, Liu Xiongbo, Zhang Jiao, Yu Bin, Zhang Wei, Qu Junle. Low Photon Count Fluorescence Lifetime Analysis Based on Alternating Descent Conditional Gradient Method[J]. Chinese Journal of Lasers, 2020, 47(2): 207022

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    Paper Information

    Category: biomedical photonics and laser medicine

    Received: Oct. 31, 2019

    Accepted: --

    Published Online: Feb. 21, 2020

    The Author Email:

    DOI:10.3788/CJL202047.0207022

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