Chinese Journal of Pharmaceuticals, Volume. 56, Issue 7, 871(2025)

Synthesis and Purification of Related Substances of Voclosporin

MAI Zidan1, JIANG Bibo2, LIU Jiajia2, XU Shengjun3, ZHANG Fuli2, and ZHAO Chuanmeng2、*
Author Affiliations
  • 1College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201203
  • 2Shanghai Institute of Pharmaceutical Industry Co., Ltd., China State Institute of Pharmaceutical Industry Co., Ltd., Shanghai 201203
  • 3Boxiao (Hangzhou) Biopharmaceutical Co., Ltd., Hangzhou 311404
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    References(6)

    [2] [2] MEJA-VILET J M, ROMERO-DAZ J. Voclosporin: a novel calcineurin inhibitor for the management of lupus nephritis[J].Expert Rev Clin Immunol, 2021,17(9): 937-945.

    [4] [4] HEO Y. Voclosporin: first approval [J].Drugs, 2021,81(5): 605-610.

    [6] [6] GELDER T V, LERMA E, ENGELKE K,et al. Voclosporin: a novel calcineurin inhibitor for the treatment of lupus nephritis [J].Expert Rev Clin Pharmacol, 2022,15(5): 515-529.

    [8] [8] KUGLSTATTER A, MUELLER F, KUSZNIR E,et al. Structural basis for the cyclophilin A binding affinity and immunosuppressive potency of E-ISA247(voclosporin) [J].Acta Crystallogr D Biol Crystallogr, 2011,67(Pt 2): 119-123.

    [10] [10] JIANG B, LIU J, LI Y,et al. Synthesis and crystallization research of voclosporin [J].Org Process Res Dev, 2024,28(4): 1151-1158.

    [11] [11] ADAM J M, ABEL M, JAYARAMAN S. Process for preparation of cyclosporin an analog [P]. WO, 2004089960. 2005-01-06.

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    MAI Zidan, JIANG Bibo, LIU Jiajia, XU Shengjun, ZHANG Fuli, ZHAO Chuanmeng. Synthesis and Purification of Related Substances of Voclosporin[J]. Chinese Journal of Pharmaceuticals, 2025, 56(7): 871

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    Paper Information

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    Received: Dec. 31, 2024

    Accepted: Aug. 26, 2025

    Published Online: Aug. 26, 2025

    The Author Email: ZHAO Chuanmeng (hotcmeng@163.com)

    DOI:10.16522/j.cnki.cjph.2025.07.005

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