We demonstrated a high-power, high-energy regenerative amplifier (RA) based on Yb:CALGO crystal, which achieves a maximum average power exceeding 50 W at a repetition rate greater than 50 kHz, and a maximum pulse energy of approximately 7 mJ at a repetition rate of up to 5 kHz. After compression, 130 fs pulses with a peak power of nearly 45 GW are achieved. To the best of our knowledge, this represents the highest average power and pulse energy reported for a Yb:CALGO RA. The RA cavity is specifically designed to maintain excellent stability and output beam quality under a pumping power of 380 W, resulting in a continuous wave output power exceeding 70 W. For the seeder, a fiber laser utilizing a nonlinear amplification process, which yields broadband spectrum to support ~80 fs pulse, is employed for the high peak power pulse generation.