We report on high-performance waveguide lasers based on depressed-cladding waveguides fabricated by femtosecond laser in Tm:YGG crystals. Pumped with 1700-nm Raman fiber laser, laser performances of Tm:YGG waveguide lasers have been investigated. Benefiting from high quantum efficiency of in-band pumping scheme and high quality of depressed-cladding waveguides, the highest output power of 2.2 W has been achieved at 2 μm, with slope efficiency of 34.9 %. This is, to the best of our knowledge, the record power ever reported from such 2-µm waveguide lasers. Our work is of great significance to fabricate high-performance and high-power waveguide lasers in integrated photonics.