Researching | Autophagy regulates ionizing radiation-induced primary ciliogenesis in glioblastoma cells

Journal of Radiation Research and Radiation Processing, Volume. 42, Issue 2, 020301(2024)

Autophagy regulates ionizing radiation-induced primary ciliogenesis in glioblastoma cells

Liangliang JIN1... Feifei YU2, Tongshan ZHANG3,4, Jinpeng HE3,4,* and Yanli YANG1,** |Show fewer author(s)

Author Affiliations

¹Department of Pathology, The 940th Hospital of Joint Logistics Support force of Chinese People’s Liberation Army, Lanzhou 730050, China

²School of Life Sciences, Lanzhou University, Lanzhou 730000, China

³Key Laboratory of Space Radiobiology of Gansu Province, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China

⁴University of Chinese Academy of Sciences, Beijing 100049, China

show less

Abstract Get PDF(in Chinese)

Figures&Tables (5)

References (26)

Paper Information

References(26)

[1] Z Anvarian, K Mykytyn, S Mukhopadhyay et al. Cellular signalling by primary cilia in development, organ function and disease. Nature Reviews Nephrology, 15, 199-219(2019).

[2] A A Kiseleva, A S Nikonova, E A Golemis. Patterns of ciliation and ciliary signaling in cancer. Reviews of Physiology, Biochemistry and Pharmacology, 185, 87-105(2023).

[3] P C Conroy, C Saladino, T J Dantas et al. C-NAP1 and rootletin restrain DNA damage-induced centriole splitting and facilitate ciliogenesis. Cell Cycle, 11, 3769-3778(2012).

[4] A Filipová, D Diaz-Garcia, A Bezrouk et al. Ionizing radiation increases primary cilia incidence and induces multiciliation in C2C12 myoblasts. Cell Biology International, 39, 943-953(2015).

[5] M Shimada, H Tsuchiya, Y Matsumoto. Effect of different dose rates of ionizing radiation on ciliogenesis in hTERT-RPE1 cells. Energy Procedia, 131, 444-447(2017).

[6] L Wei, W Ma, H Cai et al. Inhibition of ciliogenesis enhances the cellular sensitivity to temozolomide and ionizing radiation in human glioblastoma cells. Biomedical and Environmental Sciences, 35, 419-436(2022).

[7] A D Jenks, S Vyse, J P Wong et al. Primary cilia mediate diverse kinase inhibitor resistance mechanisms in cancer. Cell Reports, 23, 3042-3055(2018).

[8] S O Kim, B Y Kim, K H Lee. Synergistic effect of anticancer drug resistance and Wnt3a on primary ciliogenesis in A549 cell-derived anticancer drug-resistant subcell lines. Biochemical and Biophysical Research Communications, 635, 1-11(2022).

[9] Y Y Chao, B M Huang, I C Peng et al. ATM- and ATR-induced primary ciliogenesis promotes cisplatin resistance in pancreatic ductal adenocarcinoma. Journal of Cellular Physiology, 237, 4487-4503(2022).

[10] Wei MA, Qinglong MA, Li WEI et al. Ionizing radiation promotes primary ciliogenesis in glioblastoma cells. Journal of Radiation Research and Radiation Processing, 39, 020301(2021).

[11] K Hua, R J Ferland. Fixation methods can differentially affect ciliary protein immunolabeling. Cilia, 6, 5(2017).

[12] I Dikic, Z Elazar. Mechanism and medical implications of mammalian autophagy. Nature Reviews Molecular Cell Biology, 19, 349-364(2018).

[13] Z M Tang, M G Lin, T R Stowe et al. Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites. Nature, 502, 254-257(2013).

[14] B Carroll, G Nelson, Y Rabanal-Ruiz et al. Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing. The Journal of Cell Biology, 216, 1949-1957(2017).

[15] T Y Chen, B M Huang, T K Tang et al. Genotoxic stress-activated DNA-PK-p53 cascade and autophagy cooperatively induce ciliogenesis to maintain the DNA damage response. Cell Death & Differentiation, 28, 1865-1879(2021).

[16] Y N Teng, H C Chang, Y Y Chao et al. Etoposide triggers cellular senescence by inducing multiple centrosomes and primary cilia in adrenocortical tumor cells. Cells, 10, 1466(2021).

[17] M Liu, W Zhang, M Li et al. NudCL2 is an autophagy receptor that mediates selective autophagic degradation of CP110 at mother centrioles to promote ciliogenesis. Cell Research, 31, 1199-1211(2021).

[18] O Pampliega, I Orhon, B Patel et al. Functional interaction between autophagy and ciliogenesis. Nature, 502, 194-200(2013).

[19] S X Wang, M J Livingston, Y C Su et al. Reciprocal regulation of cilia and autophagy via the MTOR and proteasome pathways. Autophagy, 11, 607-616(2015).

[20] M S Shim, A Dixon, A Nettesheim et al. Shear stress induces autophagy in Schlemm's canal cells via primary cilia-mediated SMAD2/3 signaling pathway. Autophagy Reports, 2, 2236519(2023).

[21] M Morleo, H L A Vieira, P Pennekamp et al. Crosstalk between cilia and autophagy: implication for human diseases. Autophagy, 19, 24-43(2023).

[22] P Carotenuto, S A Gradilone, B Franco. Cilia and cancer: from molecular genetics to therapeutic strategies. Genes, 14, 1428(2023).

[23] M Morleo, B Franco. The autophagy-cilia axis: an intricate relationship. Cells, 8, 905(2019).

[24] Y Loskutov, E N Pugacheva. Targeting primary cilia - associated signaling in glioblastoma: guided approach for drug development. Oncoscience, 6, 289-290(2019).

[25] C G Morrison. Primary cilia and the DNA damage response: linking a cellular antenna and nuclear signals. Biochemical Society Transactions, 49, 829-841(2021).

[26] V Kumar, M Vashishta, L Kong et al. The role of Notch, hedgehog, and Wnt signaling pathways in the resistance of tumors to anticancer therapies. Frontiers in Cell and Developmental Biology, 9, 650772(2021).

Tools

Get Citation

Copy Citation Text

Liangliang JIN, Feifei YU, Tongshan ZHANG, Jinpeng HE, Yanli YANG. Autophagy regulates ionizing radiation-induced primary ciliogenesis in glioblastoma cells[J]. Journal of Radiation Research and Radiation Processing, 2024, 42(2): 020301

Download Citation

EndNote(RIS)BibTex Plain Text

Set citation alerts for article

Save article for my favorites

Paper Information

Category: Research Articles

Received: Nov. 21, 2023

Accepted: Dec. 29, 2023

Published Online: May. 28, 2024

The Author Email: HE Jinpeng (何进鹏), YANG Yanli (杨艳丽)

DOI:10.11889/j.1000-3436.2023-0104

Topics

laser devices and laser physics

Lasers and Laser Optics

laser manufacturing

Instrumentation, Measurement and Metrology