Nano-reinforced substrate integration in SERS microfluidic chip for bacteria detection

Shifang LI; Hong HE; Chuang GE; Li CHEN; Yi XU

doi:10.37188/OPE.20223014.1643

Optics and Precision Engineering, Volume. 30, Issue 14, 1643(2022)

Nano-reinforced substrate integration in SERS microfluidic chip for bacteria detection

Shifang LI1...2, Hong HE1,3, Chuang GE4,*, Li CHEN1,3, and Yi XU13,* |Show fewer author(s)

¹Key Disciplines Lab of Novel Micro-Nano Devices and System Technology & Key Laboratory of Optoelectronic Technology and Systems， Ministry of Education， Chongqing University， Chongqing400044， China

²School of Chemistry and Chemical Engineering， Chongqing University， Chongqing400044， China

³School of Optoelectronic Engineering， Chongqing University， Chongqing400044， China

⁴Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment， Chongqing University Cancer Hospital， Chongqing00030， China

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Fig. 1. Microfluidic SERS chip integrated with mixed microchannels^{［32-33，35-36］}

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Fig. 2. Microfluidic SERS chip based on fixed ordered nano-substrate in microchannel^［41-45］

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Fig. 3. Microfluidic SERS chip based on in-situ preparation of ordered nano-substrate in microfluidic channel^{［42-43，45-46］}

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Fig. 4. Microfluidic SERS chip for bacteria separated， concentrated and detection^［68-70］

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Table 1. SERS enhanced substrate based on composite nanomaterials

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Table 1. SERS enhanced substrate based on composite nanomaterials

SERS基底材料种类	特点	举例
贵金属纳米材料^［20］	制备简单但选择性、重现性、稳定性差	Ag、Au、Cu、
复合贵金属纳米材料^［21-23］	稳定性好、良好的生物相容性	Au@Ag、Ag@Au、Au@Pt
磁性纳米材料^［24-26］	利用磁性可实现检测物的检测分离富集，提高SERS检测灵敏度、简化复杂样品预处理	Fe₃O₄/Ag、Fe₃O₄@Au、 Ni/Au、Ni/Ag
半导体复合材料^［27^-^29］	SERS化学增强、光电催化特性	Ag/TiO₂、Ag/ZnO、Ag/CuO、Si/Au
石墨烯纳米复合材料^［30^-^31］	表面积大、光学特性好、易进行功能化改性、导电性好、荧光背景信号低	CNTs/Ag NPs、GO/Ag

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Shifang LI, Hong HE, Chuang GE, Li CHEN, Yi XU. Nano-reinforced substrate integration in SERS microfluidic chip for bacteria detection[J]. Optics and Precision Engineering, 2022, 30(14): 1643

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