Laser & Optoelectronics Progress, Volume. 60, Issue 13, 1316001(2023)
Development and Application of Nano-Optogenetic Probes
Optogenetic nanoprobes are an important technique in optogenetics, utilized to deliver precise light stimulation to neurons in organisms, aiding neuroscientists in investigating the working mechanisms of the brain. Optogenetic nanoprobes have the potential to be used in the diagnosis and treatment of neurological disorders. To fulfill stimulation requirements such as stimulation intensity, stimulation range, stimulation patterns, and temporal and spatial resolution, researchers have developed probes capable of performing various optical functions. To fulfill functional requirements such as in-situ electrophysiological recording and delivery of chemical or biological molecules, scientists have developed multi-functional probes. In order to overcome the disadvantages of traditional optoelectronic devices, as they are rigid and easy to cause severe damage to organisms, flexible optical neural probes have been invented. This type of probe causes minimal harm to the organism during implantation and maintains a consistent level of light illumination, ensuring a prolonged life span. This paper provides an overview and the prospects for different types and functions of optogenetic probes, as well as their flexible technologies.
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Yiheng Tang, Yang Weng, Zequn Chen, Xiaojing Li, Ke Si, Wei Gong, Hongtao Lin, Lan Li. Development and Application of Nano-Optogenetic Probes[J]. Laser & Optoelectronics Progress, 2023, 60(13): 1316001
Category: Materials
Received: Jun. 1, 2023
Accepted: Jun. 21, 2023
Published Online: Jul. 28, 2023
The Author Email: Li Lan (lilan@westlake.edu.cn)