Laser & Optoelectronics Progress, Volume. 60, Issue 13, 1316001(2023)

Development and Application of Nano-Optogenetic Probes

Yiheng Tang1,2, Yang Weng1,2, Zequn Chen1,2, Xiaojing Li3,4, Ke Si3,4,5, Wei Gong3,4, Hongtao Lin4,6, and Lan Li1,2、*
Author Affiliations
  • 1Key Laboratory of 3D Micro/Nano Fabrication and Characterization of Zhejiang Province, School of Engineering, Westlake University, Hangzhou 310030, Zhejiang, China
  • 2Institute of Advanced Technology, Westlake Institute for Advanced Study, Hangzhou 310024, Zhejiang, China
  • 3School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou 310058, Zhejiang, China
  • 4MOE Frontier Science Center for Brain Research and Brain-Machine Integration, Hangzhou 310058, Zhejiang, China
  • 5College of Optical Science and Engineering, Zhejiang University, Hangzhou 310027, Zhejiang, China
  • 6College of Information Science and Electronic Engineering, Zhejiang University, Hangzhou 310027, Zhejiang, China
  • show less

    Optogenetic nanoprobes are an important technique in optogenetics, utilized to deliver precise light stimulation to neurons in organisms, aiding neuroscientists in investigating the working mechanisms of the brain. Optogenetic nanoprobes have the potential to be used in the diagnosis and treatment of neurological disorders. To fulfill stimulation requirements such as stimulation intensity, stimulation range, stimulation patterns, and temporal and spatial resolution, researchers have developed probes capable of performing various optical functions. To fulfill functional requirements such as in-situ electrophysiological recording and delivery of chemical or biological molecules, scientists have developed multi-functional probes. In order to overcome the disadvantages of traditional optoelectronic devices, as they are rigid and easy to cause severe damage to organisms, flexible optical neural probes have been invented. This type of probe causes minimal harm to the organism during implantation and maintains a consistent level of light illumination, ensuring a prolonged life span. This paper provides an overview and the prospects for different types and functions of optogenetic probes, as well as their flexible technologies.

    Tools

    Get Citation

    Copy Citation Text

    Yiheng Tang, Yang Weng, Zequn Chen, Xiaojing Li, Ke Si, Wei Gong, Hongtao Lin, Lan Li. Development and Application of Nano-Optogenetic Probes[J]. Laser & Optoelectronics Progress, 2023, 60(13): 1316001

    Download Citation

    EndNote(RIS)BibTexPlain Text
    Save article for my favorites
    Paper Information

    Category: Materials

    Received: Jun. 1, 2023

    Accepted: Jun. 21, 2023

    Published Online: Jul. 28, 2023

    The Author Email: Li Lan (lilan@westlake.edu.cn)

    DOI:10.3788/LOP231425

    Topics