Taking inspiration from the in-situ reduction technique employed for exsolved nano-metal as anodes in solid oxide fuel cells (SOFCs), this study utilized Sr₂V_0.1Co_0.9MoO₆, which was synthesized in an ambient air environment, with perovskites of other phases to co-fire with the electrolyte under atmospheric conditions for direct fabrication of a single cell. By this way, the procedure of subjecting the cell to harsh preparative conditions in a reducing/inert atmosphere to prevent its anodic oxidation can be circumvented. After preparation of the anode precursor on the electrolyte sheet, we adopted a simple process of in-situ reduction at 750 ℃ for 4 h on the fuel side to achieve formation of a pure phase Sr₂V_0.1Co_0.9MoO₆ (R-SVCMO) as anode. The results demonstrate a significant reduction in the activation energy of R-SVCMO, accompanied by an increase in conductivity from 2.7 to 21.6 S•cm^-1. Moreover, when employing R-SVCMO as anode in a single cell with H₂ and wet CH₄ as fuel gases, the maximum power density (P_max) at 850 ℃ can reach up to 862 and 514 mW·cm^-2, respectively, showcasing exceptional catalytic performance. The anodes before and after reduction exhibit average thermal expansion coefficient (TEC) of 1.15×10^-5 and 1.23×10^-5 K^-1, respectively, within the temperature range of 100-850 ℃, comparable to those observed in conventional SOFC electrolytes. Therefore, the reduction process does not induce any volumetric changes in the anode layer, significantly enhancing its structural stability. Meanwhile, degradation rate of only 0.13% is occurred. It is worth noting that this R-SVCMO synthesis method can result in remarkable long-term stability and high catalytic activity as an anode material. The obtained R-SVCMO can achieve a 60% catalytic efficiency for wet CH₄ and last for 1450 h. Based on this R-SVCMO, the single cell can maintain stability for 450 h at 0.7 V. In conclusion, this study demonstrates an effective way of employing an in-situ fuel reduction method to prepare a single cell with exceptional electrochemical performance and structural stability.