Acta Photonica Sinica, Volume. 52, Issue 3, 0352104(2023)
Analysis of the Application Progress in Laser-induced Breakdown Spectroscopy：A Review（Invited）
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Fig. 4. Experimental setup for the online composition measurement of molten aluminum［41］
Fig. 7. LIBS multi-elemental imaging combined with histopathological analysis［67］
Fig. 9. Schematic diagram of the experimental setup for discharge-assisted LIBS［89］
Table 1. Literature on LIBS detection of cancer in recent five years
View tableView in ArticleTable 1. Literature on LIBS detection of cancer in recent five years
Types Samples Substrate Methods Accruacy References Ovarian cancer Blood plasma A high purity graphite plate BPNN Sensitivity=71.4%，specificity=86.5% ［ 49 ］Ovarian cancer Blood plasma PVDF substrate LDA，RF ACC>79.6% ［ 50 ］Lymphoma Blood Filter paper PCA，LDA，KNN ACC>99.7%，sensitivity >0.996，specificity >0.997 ［ 52 ］Lymphoma Serum Filter paper PCA，LDA，QDA，KNN AUC = 0.990，sensitivity = 0.970，specificity = 0.956 ［ 51 ］Multiple myeloma Serum Filter paper PCA，LDA，QDA，KNN AUC = 0.986，sensitivity = 0.892，specificity = 0.994 ［ 51 ］Blood cancer Serum Boric acid substrate KNN，LDA，RSM-LDA ACC>94.33% ［ 53 ］Melanoma Homogenized pellets，tissues — PCA，LDA Tissues：sensitivity=96.7%，specificity=99.7%
pellets：sensitivity=96.7%，specificity=99.7%
［ 54 ］Melanoma Blood，tissue homogenates PVDF，Cu，Al，Si LDA，FDA，SVM，GB ACC=96% ［ 55 ］Melanoma Blood，tissue homogenates Paraffin-embedded ANN，LDA，QDA，PLS-DA ACC=100% ［ 56 ］Glioma Fresh glioma samples，border infiltrated tissues Paraffin-embedded and fresh tissue SVM，KNN ACC=95% ［ 57 ］Brain tumor Brain tumor tissue Paraffin-embedded MFS，SNN，ANN，KNN，SVM ACC=88.62% ［ 58 ］Nasopharyngeal carcinoma Serum Boric acid substrate KNN，ELM，RF ACC=98.33%，sensitivity=99.02%，specificity =97.75% ［ 59 ］Cervical cancer Normal tissue，cervical cancer samples Paraffin-embedded PCA，SVM ACC= 94.44% ［ 60 ］Lung cancer Lung tumor tissue，boundary tissue Liquid nitrogen PCA，RF，SVM，BT ACC=98.9%，sensitivity=99.3%，specificity=98.6% ［ 61 ］
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Lianbo GUO, Xuechen NIU, Mengsheng ZHANG, Jiayuan ZHOU, Deng ZHANG, Bin LIU. Analysis of the Application Progress in Laser-induced Breakdown Spectroscopy：A Review（Invited）[J]. Acta Photonica Sinica, 2023, 52(3): 0352104
Paper Information
Category: Special Issue for Frontiers and Techniques of Laser Spectroscopy
Received: Oct. 24, 2022
Accepted: Nov. 25, 2022
Published Online: Jun. 21, 2023
The Author Email: Lianbo GUO (lbguo@hust.edu.cn), Bin LIU (918339559@qq.com)
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