[1] Haraguchi H. Metallomics: integrated biometal science[M]. Ogra Y, Hirata T. Metallomics, 3-39(2017).

[2] Zabłocka-Słowińska K, Płaczkowska S, Prescha A et al. Serum and whole blood Zn, Cu and Mn profiles and their relation to redox status in lung cancer patients[J]. Journal of Trace Elements in Medicine and Biology, 45, 78-84(2018).

[3] Liao S J, Omage S O, Börmel L et al. Vitamin E and metabolic health: relevance of interactions with other micronutrients[J]. Antioxidants, 11, 1785(2022).

[4] Li S W, Jiang X, Luo Y H et al. Sodium/calcium overload and Sirt1/Nrf2/OH-1 pathway are critical events in mercuric chloride-induced nephrotoxicity[J]. Chemosphere, 234, 579-588(2019).

[5] Renata R B N, Arely G R A, Gabriela L M A et al. Immunomodulatory role of microelements in COVID-19 outcome: a relationship with nutritional status[J]. Biological Trace Element Research, 201, 1596-1614(2023).

[6] Ge E J, Bush A I, Casini A et al. Connecting copper and cancer: from transition metal signalling to metalloplasia[J]. Nature Reviews Cancer, 22, 102-113(2022).

[7] Squitti R, Ventriglia M, Simonelli I et al. Copper imbalance in Alzheimer’s disease: meta-analysis of serum, plasma, and brain specimens, and replication study evaluating ATP7B gene variants[J]. Biomolecules, 11, 960(2021).

[8] Lee Y H, Bang E S, Lee J H et al. Serum concentrations of trace elements zinc, copper, selenium, and manganese in critically ill patients[J]. Biological Trace Element Research, 188, 316-325(2019).

[9] Chitturi R, Baddam V R, Prasad L et al. A review on role of essential trace elements in health and disease[J]. Journal of Dr NTR University of Health Sciences, 4, 75(2015).

[10] Hussain Shah S K, Iqbal J, Ahmad P et al. Laser induced breakdown spectroscopy methods and applications: a comprehensive review[J]. Radiation Physics and Chemistry, 170, 108666(2020).

[11] Ji H W, Ding Y, Zhang L W et al. Review of aerosol analysis by laser-induced breakdown spectroscopy[J]. Applied Spectroscopy Reviews, 56, 193-220(2021).

[12] Li N, Tang S H, Lu M J et al. Influence of laser wavelength on laser-induced breakdown spectrum and evolution of cavitation bubbles in water[J]. Acta Optica Sinica, 42, 1801005(2022).

[13] Fu Y X, Jia R, Xu P et al. An exploration of matrix effect on optimal defocus distance of metal matrix in laser-induced breakdown spectroscopy[J]. Chinese Journal of Lasers, 49, 1311003(2022).

[14] Guo L B, Zhang D, Sun L X et al. Development in the application of laser-induced breakdown spectroscopy in recent years: a review[J]. Frontiers of Physics, 16, 1-25(2021).

[15] Yu K Q, Ren J, Zhao Y R. Principles, developments and applications of laser-induced breakdown spectroscopy in agriculture: a review[J]. Artificial Intelligence in Agriculture, 4, 127-139(2020).

[16] Li X Y, Liu K, Zhou R et al. Summary of laser-induced breakdown spectroscopy technology and its application[J]. Chinese Journal of Lasers, 49, 1202003(2022).

[17] Palleschi V. Laser-induced breakdown spectroscopy: principles of the technique and future trends[J]. ChemTexts, 6, 1-16(2020).

[18] Fabre C. Advances in Laser-Induced Breakdown Spectroscopy analysis for geology: a critical review[J]. Spectrochimica Acta Part B: Atomic Spectroscopy, 166, 105799(2020).

[19] Fu Y T, Gu W L, Hou Z Y et al. Mechanism of signal uncertainty generation for laser-induced breakdown spectroscopy[J]. Frontiers of Physics, 16, 1-10(2020).

[20] Ciucci A, Corsi M, Palleschi V et al. New procedure for quantitative elemental analysis by laser-induced plasma spectroscopy[J]. Applied Spectroscopy, 53, 960-964(1999).

[21] Hu Z L, Zhang D, Wang W L et al. A review of calibration-free laser-induced breakdown spectroscopy[J]. TrAC Trends in Analytical Chemistry, 152, 116618(2022).

[22] Zhang D X, Zhang H, Zhao Y et al. A brief review of new data analysis methods of laser-induced breakdown spectroscopy: machine learning[J]. Applied Spectroscopy Reviews, 57, 89-111(2022).

[23] Feng Z Q, Li S S, Gu T Y et al. Electrolyte analysis in blood serum by laser-induced breakdown spectroscopy using a portable laser[J]. Molecules, 27, 6438(2022).

[24] Ghazi-Maghrebi F, Shirvani-Mahdavi H, Shoursheini S Z. Qualitative and quantitative evaluation of blood cholesterol using laser plasma spectroscopy and calibration-based linear discriminant analysis[J]. Applied Physics B, 126, 1-10(2020).

[25] Multari R A, Cremers D A, Nelson A et al. The use of laser-based diagnostics for the rapid identification of infectious agents in human blood[J]. Journal of Applied Microbiology, 126, 1606-1617(2019).

[26] Šindelářová A, Pořízka P, Modlitbová P et al. Methodology for the implementation of internal standard to laser-induced breakdown spectroscopy analysis of soft tissues[J]. Sensors, 21, 900(2021).

[27] Emara E M, Song H Y, Imam H et al. Detection of hypokalemia disorder and its relation with hypercalcemia in blood serum using LIBS technique for patients of colorectal cancer grade I and grade II[J]. Lasers in Medical Science, 37, 1081-1093(2022).

[28] Musyoka Wayua D, Kalambuka Angeyo H, Dehayem-Kamadjeu A et al. Direct analysis of blood for diagnostic metals for malaria by peak-free laser-induced breakdown spectroscopy (LIBS) with artificial neural networks (ANN) and partial least squares (PLS)[J]. Analytical Letters, 55, 2669-2682(2022).

[29] Gaudiuso R, Ewusi-Annan E, Melikechi N et al. Using LIBS to diagnose melanoma in biomedical fluids deposited on solid substrates: limits of direct spectral analysis and capability of machine learning[J]. Spectrochimica Acta Part B: Atomic Spectroscopy, 146, 106-114(2018).

[30] Chen X, Zhang Y, Li X H et al. Diagnosis and staging of multiple myeloma using serum-based laser-induced breakdown spectroscopy combined with machine learning methods[J]. Biomedical Optics Express, 12, 3584-3596(2021).

[31] Eum C, Park J, Kumar S et al. Feasibility of laser-induced breakdown spectroscopy as a direct raw bile analysis tool for screening of gallbladder cancer[J]. Journal of Analytical Atomic Spectrometry, 37, 823-832(2022).

[32] Teng G E, Wang Q Q, Yang H F et al. Pathological identification of brain tumors based on the characteristics of molecular fragments generated by laser ablation combined with a spiking neural network[J]. Biomedical Optics Express, 11, 4276-4289(2020).

[33] Li J J, Chen F, Huang G Q et al. Identification of Graves’ophthalmology by laser-induced breakdown spectroscopy combined with machine learning method[J]. Frontiers of Optoelectronics, 14, 321-328(2021).

[34] Pyun S H, Min W, Goo B et al. Real-time, in vivo skin cancer triage by laser-induced plasma spectroscopy combined with a deep learning-based diagnostic algorithm[J]. Journal of the American Academy of Dermatology, 1166(2022).

[35] Cherni I, Nouir R, Daoud F et al. Fast diagnostic of osteoporosis based on hair analysis using LIBS technique[J]. Medical Engineering & Physics, 103, 103798(2022).

[36] Nouir R, Cherni I, Ghalila H et al. Early diagnosis of dental pathologies by front face fluorescence (FFF) and laser-induced breakdown spectroscopy (LIBS) with principal component analysis (PCA)[J]. Instrumentation Science & Technology, 50, 465-480(2022).

[37] Nordberg M, Nordberg G F. Trace element research-historical and future aspects[J]. Journal of Trace Elements in Medicine and Biology, 38, 46-52(2016).

[38] Lelièvre P, Sancey L, Coll J L et al. The multifaceted roles of copper in cancer: a trace metal element with dysregulated metabolism, but also a target or a bullet for therapy[J]. Cancers, 12, 3594(2020).

[39] Chen X, Li X H, Yang S B et al. Discrimination of lymphoma using laser-induced breakdown spectroscopy conducted on whole blood samples[J]. Biomedical Optics Express, 9, 1057-1068(2018).

[40] Chen X, Li X H, Yu X et al. Diagnosis of human malignancies using laser-induced breakdown spectroscopy in combination with chemometric methods[J]. Spectrochimica Acta Part B: Atomic Spectroscopy, 139, 63-69(2018).

[41] Chu Y W, Chen F, Sheng Z Q et al. Blood cancer diagnosis using ensemble learning based on a random subspace method in laser-induced breakdown spectroscopy[J]. Biomedical Optics Express, 11, 4191-4202(2020).

[42] Chu Y W, Chen T, Chen F et al. Discrimination of nasopharyngeal carcinoma serum using laser-induced breakdown spectroscopy combined with an extreme learning machine and random forest method[J]. Journal of Analytical Atomic Spectrometry, 33, 2083-2088(2018).

[43] Gaudiuso R, Ewusi-Annan E, Xia W M et al. Diagnosis of Alzheimer’s disease using laser-induced breakdown spectroscopy and machine learning[J]. Spectrochimica Acta Part B: Atomic Spectroscopy, 171, 105931(2020).

[44] Berlo K, Xia W, Zwillich F et al. Laser induced breakdown spectroscopy for the rapid detection of SARS-CoV-2 immune response in plasma[J]. Scientific Reports, 12, 1614(2022).

[45] Chu Y W, Zhang Z J, He Q Y et al. Half-life determination of inorganic-organic hybrid nanomaterials in mice using laser-induced breakdown spectroscopy[J]. Journal of Advanced Research, 24, 353-361(2020).

[46] Zhao Z F, Ma W P, Teng G E et al. Accurate identification of inflammation in blood based on laser-induced breakdown spectroscopy using chemometric methods[J]. Spectrochimica Acta Part B: Atomic Spectroscopy, 202, 106644(2023).

[47] Zhang K, Xu Z W, Chen C S et al. Application prospect of laser induced breakdown spectroscopy in disease diagnosis[J]. Spectroscopy and Spectral Analysis, 41, 1961-1965(2021).

[48] Wang Q Q, Xiangli W T, Teng G E et al. A brief review of laser-induced breakdown spectroscopy for human and animal soft tissues: pathological diagnosis and physiological detection[J]. Applied Spectroscopy Reviews, 56, 221-241(2021).

[49] Luo M, Li X H, He Q X et al. Elemental analysis and identification of papillary thyroid cancer tissues using laser-induced breakdown spectroscopy[J]. Journal of Analytical Atomic Spectrometry, 37, 833-840(2022).

[50] Wang J, Li L, Yang P et al. Identification of cervical cancer using laser-induced breakdown spectroscopy coupled with principal component analysis and support vector machine[J]. Lasers in Medical Science, 33, 1381-1386(2018).

[51] Khan M N, Wang Q Q, Idrees B S et al. Evaluation of human melanoma and normal formalin paraffin-fixed samples using Raman and LIBS fused data[J]. Lasers in Medical Science, 37, 2489-2499(2022).

[52] Lin Q Y, Wei H Y, Yin P K et al. Discrimination of elemental responsiveness to tumor chemotherapy by laser-induced breakdown spectroscopy coupled with chemometric methods[J]. Laser Physics, 30, 105701(2020).

[53] Panda S M, Chatterjee O, Roy L et al. Targeting Ca2+ signaling: a new arsenal against cancer[J]. Drug Discovery Today, 27, 923-934(2022).

[54] Lin X M, Sun H R, Gao X et al. Discrimination of lung tumor and boundary tissues based on laser-induced breakdown spectroscopy and machine learning[J]. Spectrochimica Acta Part B: Atomic Spectroscopy, 180, 106200(2021).

[55] Teng G E, Wang Q Q, Zhang H W et al. Discrimination of infiltrative glioma boundary based on laser-induced breakdown spectroscopy[J]. Spectrochimica Acta Part B: Atomic Spectroscopy, 165, 105787(2020).

[56] Wang Q Q, Xiangli W T, Chen X H et al. Primary study of identification of parathyroid gland based on laser-induced breakdown spectroscopy[J]. Biomedical Optics Express, 12, 1999-2014(2021).

[57] Cherni I, Nakkach M, Ghalila H et al. Noninvasive diagnosis of type 2 diabetes mellitus by hair analysis using laser-induced breakdown spectroscopy (LIBS)[J]. Instrumentation Science & Technology, 51, 16-31(2023).

[58] Zhang S Y, Chu Y W, Ma S X et al. Highly accurate determination of Zn and Cu in human hair by ultrasound-assisted alkali dissolution combined with laser-induced breakdown spectroscopy[J]. Microchemical Journal, 157, 105018(2020).

[59] Zhang S Y, Hu Z L, Zhao Z F et al. Quantitative analysis of mineral elements in hair and nails using calibration-free laser-induced breakdown spectroscopy[J]. Optik, 242, 167067(2021).

[60] Muhammed S K M, Chawla A, Mallya M et al. Laser-induced breakdown spectroscopy-Raman: an effective complementary approach to analyze renal-calculi[J]. Journal of Biophotonics, 11, e201700271(2018).

[61] Liu Z K, Li S K, Xia X et al. Recent advances in multifunctional graphitic nanocapsules for Raman detection, imaging, and therapy[J]. Small Methods, 4, 1900440(2020).

[62] Luo X F, You L B, Xu J et al. Research progress of elemental imaging technology based on laser-induced breakdown spectroscopy[J]. Laser Technology, 44, 66-73(2020).

[63] Moncayo S, Duponchel L, Mousavipak N et al. Exploration of megapixel hyperspectral LIBS images using principal component analysis[J]. Journal of Analytical Atomic Spectrometry, 33, 210-220(2018).

[64] Meng Y F, Gao C H, Lin Z et al. Nanoscale laser-induced breakdown spectroscopy imaging reveals chemical distribution with subcellular resolution[J]. Nanoscale Advances, 2, 3983-3990(2020).

[65] Limbeck A, Brunnbauer L, Lohninger H et al. Methodology and applications of elemental mapping by laser induced breakdown spectroscopy[J]. Analytica Chimica Acta, 1147, 72-98(2021).

[66] Gimenez Y, Busser B, Trichard F et al. 3D imaging of nanoparticle distribution in biological tissue by laser-induced breakdown spectroscopy[J]. Scientific Reports, 6, 29936(2016).

[67] Moncayo S, Trichard F, Busser B et al. Multi-elemental imaging of paraffin-embedded human samples by laser-induced breakdown spectroscopy[J]. Spectrochimica Acta Part B: Atomic Spectroscopy, 133, 40-44(2017).

[68] Kiss K, Šindelářová A, Krbal L et al. Imaging margins of skin tumors using laser-induced breakdown spectroscopy and machine learning[J]. Journal of Analytical Atomic Spectrometry, 36, 909-916(2021).

[69] Yin P K, Hu B, Li Q et al. Imaging of tumor boundary based on multielements and molecular fragments heterogeneity in lung cancer[J]. IEEE Transactions on Instrumentation and Measurement, 70, 4006207(2021).

[70] le Guével X, Henry M, Motto-Ros V et al. Elemental and optical imaging evaluation of zwitterionic gold nanoclusters in glioblastoma mouse models[J]. Nanoscale, 10, 18657-18664(2018).

[71] Busser B, Bulin A L, Gardette V et al. Visualizing the cerebral distribution of chemical elements: a challenge met with LIBS elemental imaging[J]. Journal of Neuroscience Methods, 379, 109676(2022).

[72] Wei H Y, Zhao Z, Lin Q Y et al. Study on the molecular mechanisms against human breast cancer from insight of elemental distribution in tissue based on laser-induced breakdown spectroscopy (LIBS)[J]. Biological Trace Element Research, 199, 1686-1692(2021).

[73] Lin Q Y, Wang S, Duan Y X et al. Ex vivo three-dimensional elemental imaging of mouse brain tissue block by laser-induced breakdown spectroscopy[J]. Journal of Biophotonics, 14, e202000479(2021).

[74] Gardette V, Motto-Ros V, Alvarez-Llamas C et al. Laser-induced breakdown spectroscopy imaging for material and biomedical applications: recent advances and future perspectives[J]. Analytical Chemistry, 95, 49-69(2023).