Journal of Radiation Research and Radiation Processing, Volume. 42, Issue 5, 050302(2024)
MCC950 ameliorates radiation induced lung injury through modulating macrophage polarization
[1] Q Dasgupta, A Jiang, A M Wen et al. A human lung alveolus-on-a-chip model of acute radiation-induced lung injury. Nature Communications, 14, 6506(2023).
[2] A N Hanania, W Mainwaring, Y T Ghebre et al. Radiation-induced lung injury: assessment and management. Chest, 156, 150-162(2019).
[3] X R Rao, D Zhou, H L Deng et al. Activation of NLRP3 inflammasome in lung epithelial cells triggers radiation-induced lung injury. Respiratory Research, 24, 25(2023).
[4] X H Wang, S B Chen, L L Zhao et al. Protective effect of combination of anakinra and MCC950 against acute lung injury is achieved through suppression of the NF-κB-mediated-MAPK and NLRP3-caspase pathways. International Immunopharmacology, 97, 107506(2021).
[5] W Yan, Y C Shen, J Huang et al. MCC950 ameliorates acute liver injury through modulating macrophage polarization and myeloid-derived suppressor cells function. Frontiers in Medicine, 8, 752223(2021).
[6] Qiong WU, Lei YUAN, Min YU et al. Effect of intermittent fasting on the cognitive dysfunction induced by irradiation. Chinese Journal of Radiological Medicine and Protection, 42, 335-342(2022).
[7] Q Wu, M Yu, Z Wang et al. Alternate-day fasting for the protection of cognitive impairment in c57BL/6J mice following whole-brain radiotherapy. Neurochemistry International, 162, 105463(2023).
[8] L Niu, S S Luo, Y Xu et al. The critical role of the hippocampal NLRP3 inflammasome in social isolation-induced cognitive impairment in male mice. Neurobiology of Learning and Memory, 175, 107301(2020).
[9] L Zheng, Q Zhu, C Xu et al. Glycyrrhizin mitigates radiation-induced acute lung injury by inhibiting the HMGB1/TLR4 signalling pathway. Journal of Cellular and Molecular Medicine, 24, 214-226(2020).
[10] L Interdonato, R D’Amico, M Cordaro et al. Aerosol-administered adelmidrol attenuates lung inflammation in a murine model of acute lung injury. Biomolecules, 12, 1308(2022).
[11] Huiqing LIU. The mechanism of NMN activating SIRT2-mediated glycolysis pathway to improve follicular development in PCOS rats(2021).
[12] Yanhui LI, Xin WU, Tan WANG et al. Effects of different courses of electrotherapy on learning, memory, and Notch signaling in a mouse model of radiation-induced brain injury. Journal of Radiation Research and Radiation Processing, 41, 050301(2023).
[13] F Heinzelmann, V Jendrossek, K Lauber et al. Irradiation-induced pneumonitis mediated by the CD95/CD95-ligand system. Journal of the National Cancer Institute, 98, 1248-1251(2006).
[14] Yizhe XUE, Zhaowen ZHANG, Ling GUO et al. Effects of 5G mobile phone radiation on sperm quality and sex hormone levels in mice. Journal of Radiation Research and Radiation Processing, 41, 010301(2023).
[15] S Siva, A V Louie, R Kotecha et al. Stereotactic body radiotherapy for primary renal cell carcinoma: a systematic review and practice guideline from the International Society of Stereotactic Radiosurgery (ISRS). The Lancet Oncology, 25, e18-e28(2024).
[16] A E Hird, D E Magee, R Matta et al. Assessment of secondary sarcomas among patients with cancer of the abdomen or pelvis who received combinations of surgery, radiation, and chemotherapy vs surgery alone. JAMA Network Open, 3, e2013929(2020).
[17] E Hahn, A Popovtzer, B W Corn. Hyperbaric oxygen therapy for management of late radiation toxicity-a honey of a trial?. JAMA Oncology, 10, 437-438(2024).
[18] Y M Li, J C Li, Q Yu et al. METTL14 regulates microglia/macrophage polarization and NLRP3 inflammasome activation after ischemic stroke by the KAT3B-STING axis. Neurobiology of Disease, 185, 106253(2023).
[19] S Curras-Alonso, J Soulier, T Defard et al. An interactive murine single-cell atlas of the lung responses to radiation injury. Nature Communications, 14, 2445(2023).
[20] T K Xu, Y Y Zhang, P Y Chang et al. Mesenchymal stem cell-based therapy for radiation-induced lung injury. Stem Cell Research & Therapy, 9, 18(2018).
[21] L N Lu, C Sun, Q Su et al. Radiation-induced lung injury: latest molecular developments, therapeutic approaches, and clinical guidance. Clinical and Experimental Medicine, 19, 417-426(2019).
[22] T Chen, B Zhuang, Y Q Huang et al. Inhaled curcumin mesoporous polydopamine nanoparticles against radiation pneumonitis. Acta Pharmaceutica Sinica B, 12, 2522-2532(2022).
[23] K G Lee, B K Hong, S Lee et al. Nuclear receptor coactivator 6 is a critical regulator of NLRP3 inflammasome activation and gouty arthritis. Cellular & Molecular Immunology, 21, 227-244(2024).
[24] Q Q Han, W H Li, P Q Chen et al. Microglial NLRP3 inflammasome-mediated neuroinflammation and therapeutic strategies in depression. Neural Regeneration Research, 19, 1890-1898(2024).
[25] S Lyu, S R Liu, X Guo et al. hP-MSCs attenuate severe acute pancreatitis in mice via inhibiting NLRP3 inflammasome-mediated acinar cell pyroptosis. Apoptosis, 29, 920-933(2024).
[26] A Naeem, R Prakash, N Kumari et al. MCC950 reduces autophagy and improves cognitive function by inhibiting NLRP3-dependent neuroinflammation in a rat model of Alzheimer’s disease. Brain, Behavior, and Immunity, 116, 70-84(2024).
[27] Y F Liang, S J Shen, X X Ye et al. Celastrol alleviates airway hyperresponsiveness and inflammation in obese asthma through mediation of alveolar macrophage polarization. European Journal of Pharmacology, 972, 176560(2024).
[28] Xiaoyang BAI, Xu ZHANG, HAI Long et al. Regulatory effect and mechanism of macrophage polarization in liver fibrosis. Journal of Clinical Hepatology, 40, 611-615(2024).
[29] Dandan WANG, Lulu XU, Jie ZHANG. Baricitinib attenuates pulmonary fibrosis in scleroderma mice by regulating macrophage polarization. Journal of Army Medical University, 46, 128-138(2024).
[30] J J Yang, Y Pan, X S Zeng et al. Discovery of novel aporphine alkaloid derivative as potent TLR2 antagonist reversing macrophage polarization and neutrophil infiltration against acute inflammation. Acta Pharmaceutica Sinica B, 13, 3782-3801(2023).
[31] H M Saad, E Elekhnawy, M A Shaldam et al. Rosuvastatin and diosmetin inhibited the HSP70/TLR4/NF-κB p65/NLRP3 signaling pathways and switched macrophage to M2 phenotype in a rat model of acute kidney injury induced by cisplatin. Biomedicine & Pharmacotherapy, 171, 116151(2024).
[32] Aitao NAI, Zhen WANG, Dan LUO et al. Ionizing radiation induces cognitive dysfunction by activating prefrontal cortex NLRP3 inflammasome in mice. Journal of Radiation Research and Radiation Processing, 37, 040301(2019).
[33] L Vande Walle, M Lamkanfi. Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets. Nature Reviews Drug Discovery, 23, 43-66(2024).
[34] X Chen, D X Zhang, Y P Li et al. NLRP3 inflammasome and IL-1β pathway in type 2 diabetes and atherosclerosis: friend or foe?. Pharmacological Research, 173, 105885(2021).
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Zhen WANG, Suli LU, Guicheng HE, Hui YANG, Aitao NAI, Hui ZENG. MCC950 ameliorates radiation induced lung injury through modulating macrophage polarization[J]. Journal of Radiation Research and Radiation Processing, 2024, 42(5): 050302
Category: RADIOBIOLOGY AND RADIOMEDICINE
Received: Mar. 26, 2024
Accepted: May. 17, 2024
Published Online: Jan. 2, 2025
The Author Email: NAI Aitao (乃爱桃), ZENG Hui (曾慧)