Fig. 1. Effects of MCC950 on body weight of irradiated mice (p≥0.05)

Fig. 2. Effects of MCC950 on edema in lung tissue of irradiated mice: (a) the statistical analysis of the lung coefficient; (b) the statistical analysis of the lung wet/dry ratio; **compared with the control group, p < 0.01; *** compared with the control group, p < 0.001; # compared with the IR group, p < 0.05

Fig. 3. Effects of MCC950 on lung tissue damage of irradiated mice: (a) the representative images of HE staining images in the three groups of mice, bar = 100 μm; (b) score statistical analysis of lung tissue damage in the three groups of mice; **** compared with the control group, p < 0.000 1; ## compared with the IR group, p < 0.01

Fig. 4. Effects of MCC950 on NLRP3 inflammasome of irradiated mice: (a) the protein expression of NLRP3 ASC, and Caspase-1; the quantitative analysis for (b) NLRP3, (c) ASC, and (d) Caspase-1; ** compared with the control group, p < 0.01; *** compared with the control group, p < 0.001; **** compared with the control group, p < 0.000 1; # compared with the IR group, p < 0.05; ## compared with the IR group, p < 0.01

Fig. 5. Effects of MCC950 on macrophage polarization of irradiated mice: (a) expression of CD86 and CD163 proteins; the quantitative analysis for (c) CD86 and (d) CD163; * compared with the control group, p < 0.05; ** compared with the control group, p < 0.01; # compared with the IR group, p < 0.05

Fig. 6. Effects of MCC950 intervention on inflammatory factors of irradiated mice: (a) representative bands of Pro-IL-1β, IL-1β, IL-18 and TNF-a are shown for each group; the quantitative analysis for (b) Pro-IL-1β, (c) IL-1β, (d) IL-18 and (e) TNF-a; * compared with the control group, p < 0.05; *** compared with the control group, p < 0.001; **** compared with the control group, p < 0.000 1; ## compared with the IR group, p < 0.01