Uric acid is the final oxide of purine metabolism in the body and is one of the serum markers of inflammation. Persistent elevation of uric acid levels in serum can cause a series of diseases in the human body. Conventional methods for detecting uric acid have the disadvantages of expensive analytical reagents, and cumbersome and complicated chemical analysis. Detection based on terahertz metamaterial sensors is label-free and nondestructive, requires only a minute amount of reagents, does not damage analytes, and offers a high detection speed. A double-F multifrequency resonant metamaterial sensor with a maximum sensitivity of 160 GHz/RIU (RIU is a unit of refractive index) is proposed, which can be applied to high-sensitivity detection of uric acid. Different concentrations of uric acid solutions can be detected using this sensor. Results show that the lowest detection limit of the proposed sensor for uric acid solution is 0.001 g/L, which is lower than the lowest level of uric acid in a healthy human body. Thus, it is expected to be used in the detection of diseases.