In order to protect the military opto-electronic instruments from laser blinding weapons, the high and low refractive index combinations of Si and YbF3, ZnS and YbF3 are selected to design and fabricate laser protective infrared antireflection coatings. On the substrate of multi-spectral ZnS, coatings with laser protective function to 532 nm and 1064 nm laser while with high transmittance in the 3~5 μm spectral band are fabricated, and electron beam and ion assisted deposition technique is used in this process. The deposition process of Si by electron beam is studied, and the deposition process of YbF3 in different materials combination is optimized. The adhesion problem between coatings and substrate is resolved. Devices of antireflection for detection and protection are both integrated into the coatings, and the structures of opto-electronic instruments for satellite and aeroplane can be simplified. Results of spectrum analysis and environmental test show that all the parameters meet the requirements.