Compared with the traditional Nd∶YAG, the co-doped Nd,Ce∶YAG crystal has the advantages of high output energy and low laser oscillation threshold. In recent years, the development of high energy efficiency solid-state lasers requires more and more large size and high-quality Nd,Ce∶YAG crystals. When large size Nd,Ce∶YAG is grown by Czochralski method, inclusion and cracking defects are very easy to occur. In this paper, the reason of the defects formation during the crystal growth were analyzed by combining theory with practice, and the solutions were put forward. Finally, high-quality Nd,Ce∶YAG single crystal with a diameter of 50 mm and an equal length of 150 mm was successfully grown. The results can provide direction and guidance for the quality improvement of mass production of large size Nd,Ce∶YAG crystals.