In order to improve the wear resistance and corrosion resistance of TC4 alloy parts, the microstructure and comprehensive properties of laser cladding Fe35A coating on TC4 titanium alloy were analyzed through digital analysis and metallographic analysis. The results show that under the optimum parameters of laser power of 2.3kW, scanning speed of 9mm/s, and powder feeding rate of 10g/min, the best macro-morphology and good microstructure of the surface layer of TC4 is obtained. The Fe grain is refined, and the distribution is uniform. The high fusion degree between substrate and deposit is observed. The Rockwell hardness of the deposition layer is up to 40.2HRC, and the microhardness is up to 645.5HV. The overall mechanical properties of the deposition layer are obviously higher than that of the matrix. This research provides practical reference for the high quality repair and reuse of TC4 titanium alloy surface.