The gradient coating with the nickel-aluminum (KF-6) as a transition layer and with the TiB2 reinforced Ni-based composite coating as a strengthened layer is fabricated by laser cladding on copper alloy (Cr-Zr-Cu) surface with KF-6 and TiB2 as cladding materials. The study results show that the microstructural morphology of TiB2 is obviously different in the strengthened layer when the TiB2 content is different in laser cladding powders. The average microhardness of the strengthened layer is between 1150 HV and 1450 HV. The gradient coating has the lowest wear rate when the mass fraction of TiB2 is 10%. When the mass fraction of TiB2 is 30%, the coefficient friction of the gradient coating is stable (about 0.4). The transition layer between the strengthened layer and the substrate can effectively reduce the abrupt changes of the composition and microhardness between the strengthened layer and the substrate, which makes the transitions of the composition and microhardness smooth in the gradient coating.