In this paper, a continuous fiber laser was used to study the surface nitriding effect on CNC machine drive shaft by 12 groups (Group A~L) of different laser parameters. Three groups of optimum parameters were selected to study the microstructure and properties after laser nitriding, in order to lay a foundation for revealing the evolution law of microstructure, composition, and physical mechanical behavior. The results show that when the laser power and scanning speed is 1.2 kW and 3 mm·s-1 respectively, the surface roughness of the nitrided layer is Ra=1.6 μm, which is the lowest compared with other parameters. The microstructure is not only refined, but also changed from tempered sorbite to a mixture of martensite, carbide, nitride, and matrix. In addition, the microhardness, wear resistance, and tensile strength of nitriding layer are improved accordingly.参考文献原文> YANG Z J, CHEN C H, CHEN F, et al. Progress in the research of reliability technology of machine tools［J］. Journal of Mechanical Engineering, 2013, 49(20): 130-139.杨兆军, 陈传海, 陈菲, 等. 数控机床可靠性技术的研究进展［J］. 机械工程学报, 2013, 49(20): 130-139.