This study investigates the impact of varying inclination angles of the cladding nozzle on processing outcomes under different substrate inclinations using laser cladding technology with internal powder feeding. The orthogonal experiment of laser cladding was carried out by controlling the inclination angle of the substrate between 30° and 150° and rotating the inclination angle of the nozzle counterclockwise between 0°and 15°. The results show that the laser energy distribution, the influence of gravity component and the collimation protective gas pressure have different influence weights after adjusting the nozzle position under different substrate tilt states. The peak point offset of the cladding layer initially increases and then decreases with nozzle tilt angle when the substrate inclination is non-90°. Conversely, at a substrate inclination of 90°, the peak point offset decreases initially and then increases with increasing nozzle tilt angle.