This study presented the preparation and characterization of an all-solid-state PbSe QD-doped glass fiber with tunable broadband MIR emission. Based on the selection and optimization of the basic glass system, a size-controllable PbSe QD-doped glass was prepared and achieved broadband tunable emission in the MIR regions of 1.82.8 μm. The core glass was a PbSe QD-doped borosilicate glass, and the cladding glass was a PbSe QD-doped borosilicate glass. The PbSe QD-doped glass fiber was successfully prepared using the melt-in-tube melting, and it was then characterized using EPMA. There was no evidence of elemental migration in the glass fibers, which had a complete core-cladding structure. When excited by an 808 nm laser, PbSe QD-doped glass fibers produced broadband tunable emission within 1.82.8 μm, which was expected to be used as a broadband tunable MIR light source.