Objective To systematically review the efficacy and safety of percutaneous laser disc decompression (PLDD) combined with ozone injection in the treatment of lumbar disc herniation(LDH). Methods We searched PubMed, Embase, the Chochrane library, Web of Science, CBM, Wanfang Data, VIP and CNKI databases, Randomized controlled trials (RCTs) on the efficacy and safety of PLDD combined with ozone injection in the treatment of LDH were collected, and the retrieval time is from the establishment date to March 1, 2021. The two researchers independently conducted literature retrieval, screening, data extraction, literature quality and risk of bias evaluation. Meta-analysis was conducted by using RevMan 5.3 software. Results Eighteen RCTs, including 3069 patients, were eventually included. Meta-analysis results showed that: compared with use PLDD or ozone injection individually in the treatment of LDH, PLDD combined with ozone injection can significantly increase the curative effect of modified MacNab evaluation standard ［the OR=3.76, 95% CI (2.89, 4.90), P<0.000 01), reduce the Visual Analogue Scales (VAS) ［MD=-0.85，95%CI（-1.32，-0.38），P=0.0004］, improve the excellent rate of Japanese Orthopaedic Association scores, (JOA) ［OR=4.28, 95% CI (3.39, 5.41), P < 0.000 01］, the difference was statistically significant. Conclusion the existing evidence showed that, compared with the PLDD or ozone injection be used alone in the treatment of LDH，PLDD combined with ozone injection, as a kind of interventional therapy in the treatment of LDH, can improve the curative effect of modified Macnab evaluation standard, the excellent rate of Japanese Orthopaedic Association scores(JOA), reduce the Visual Analogue Scales (VAS), high security. Owing to the limitation of the quantity and quality of the included studies, the above conclusions need to be further verified by a large number of multi-center, large-sample and high-quality studies.