Nitric oxide (NO) gas therapy is a new cancer treatment method, which has the advantages of low toxicity and convenient metabolism. It can inhibit the growth of cancer cells by destroying and inhibiting DNA synthesis and repair, damaging mitochondrial organelles, etc., whereas the short half-life and uncontrollable of NO gas molecules also limit its development in the field of tumor therapy. Therefore, NO-releasing nanosystem that combine with other existent cancer treatments for synergistic anti-cancer therapy is very important. This article mainly introduces the construction and its anticancer mechanism of the multi-modal treatment of NO gas therapy combined with traditional treatment methods such as radiotherapy, ultrasound therapy, photothermal therapy, reactive oxygen species stimulation, chemotherapy. The potential application of combining NO and traditional cancer treatment methods in the field of tumor treatment are highlighted.