In this paper, a nanolaser based on hybrid plasmonic waveguide is proposed, and its theoretical research and simulation analysis are carried out. In this structure, the plasma mode of metal-dielectric interface is coupled with high gain medium semiconductor nanowire waveguide mode, which greatly increases the intermediate air gap field strength and meanwhile maintains low loss transmission. And deep subwavelength constraint to output light field is realized. By optimizing the geometric parameters of the structure, a nanolaser with smaller threshold and higher quality factors is achieved. Compared with the nanolaser of edge-coupled hybrid plasmonic waveguide, the proposed nanolaser with lower threshold can be obtained when the geometric parameters of the two lasers are the same.