To overcome the shortcomings of traditional image restoration model and total variation image restoration model, we propose a novel Hopfield neural network-based image restoration algorithm with adaptive mixed-norm regularization. The new error function of image restoration combines the L2-norm and L1-norm regularization types. A method of calculating the adaptive scale control parameter is introduced. Experimental results demonstrate that the proposed algorithm is better than other algorithms with single norm regularization in the improvement of signal-to-noise ratio (ISNR) and vision effect.