A new system is developed to adaptively collimate laser beam direction, with high speed and high accuracy. The sensing module of this system consists of an optical layout using pinhole to amplify the beam drift and a complementary metal-oxide-semiconductor transistor sensor. An field programmable gate array chip is the core of the signal processing module to perform high speed calculation and feedback control. At the aspect of software, an algorithm is designed to derive the driving signal for automatic alignment, which is capable of uncoupling the horizontal and vertical adjustment and suitable for highly accurate automatic control. Experiments are conducted to test the performance of the system. Results show that, the system implements feedback control with accuracy of 2.5 μm and the feedback frequency about 1 kHz, and can obviously reduce the beam drifting with the frequency below 1 kHz.